SERDIM (Japanese name: Skinplus)｜Effectiveness, Ingredients, and Differences from Rituo

Do you have any of these concerns or questions?

Hello. We are Smart Skin Clinic, a cosmetic dermatology clinic with over 20,000 injections per year.

This article provides a thorough, easy-to-understand explanation of the next-generation skin booster called SERDIM (SkinPlus), including its mechanism, effects, downtime, and differences from other skin boosters from the perspective of a cosmetic dermatologist.

※If you have specific topics you'd like to learn about, you can jump directly to them by selecting the relevant section from the table of contents below.

Supervisor Information

Chief Director of Smart Skin Clinic Group

stoneheterotopia KoutaHeian era court lady's song (accompanying men's oouta)

career

Graduated from Juntendo University School of Medicine

Tokyo Women's Medical University Hospital and related facilities

Worked at a major beauty clinic in Tokyo

Affiliation / Qualifications

Japan Surgical Society Specialist

Japanese Society of Anti-Aging Medicine

What is Cerdiem (Skin Plus)?

CellREDM (Korean name: CellREDM / Japanese brand name: SkinPlus) is a next-generation skin booster product manufactured by Hans Biomed, a Korean medical device and biomaterial manufacturer.

Whereas conventional treatment was based on the concept of "supplementing what is lacking from the outside (e.g., adding volume with hyaluronic acid),SERDEM's approach is to "enhance the skin's natural regenerative power itself.Take the

Principle of the ECM Skin Booster

Seldiem is classified in the category of "ECM Skin Boosters"!ECM stands for "Extracellular Matrix," which is composed of collagen, elastin, hyaluronic acid, etc., and is like the "framework" that fills in and supports the space between the cells of our skin.

To use an analogy, skin cells are the "inhabitants" and ECM is the "structure of the building. If the structure is solid, the house will last for a long time and the skin cells, which are the inhabitants, will be able to spend their time comfortably. On the other hand, if the structure is deteriorated, there is a limit no matter how much interior decoration is done.SERDIM is a treatment aimed at "restoring and strengthening" that structure.

Improvement of skin structure brought about by the main ingredient "ultrafine particle human-derived ECM (hADM)

The most distinctive feature of CellDiem is that its main ingredient is human-derived ECM (hADM: human-derived cell-free dermal matrix).

hADM is highly purified ECM components such as collagen, elastin, hyaluronic acid, and fibronectin only from donor-supplied human skin by removing cellular components that cause immune response.

By processing this ingredient into ultra-fine particles of 75µm and injecting them into the dermal layer, the skin's own fibroblasts are activated and the production of collagen and elastin is stimulated. The most distinctive feature of CELDIM is that the skin "produces" its own collagen and elastin, rather than supplementing it from the outside.

Safety is also important in human-derived preparations, Hans Biomed,Manufacture of hADMs in FDA and AATB (American Association of Tissue Bankers) certified facilitiesThe company is doing so.

5th generation skin booster

In Korean cosmetic medicine, followed by Rejuran JubelukAlso known as the "5th generation skin booster."There are times when the term "market" is used. However, this is not an officially or academically defined classification, but rather an expression used in advertising and marketing.

The same fifth-generation skin booster, Re2O, is also known as a skin booster.

Three benefits you can expect from Cerdiem

1) Restoration of firmness and elasticity (5th generation ECM approach)

Unlike conventional skin boosters that "stimulate the cells to produce collagen," the greatest feature of CELDIM is that it directly replenishes the extracellular matrix (ECM) itself, which serves as a scaffold for collagen and elastin, and supports their structure by acting as a scaffold.

The micronized hADM component spreads evenly within the dermis and supports the structure as an immediate scaffold.In addition, the "fibroblasts" are activated by entering the strong scaffold and generate and remodel new collagen and elastin, resulting in the revival of firmness and elasticity that seems to come from deep within the skin, rather than unnatural puffiness.

A 2017 study (Micronized Cross-Linked Human Acellular Dermal Matrices) confirmed that micronized hADM acts as a scaffold for collagen synthesis. After the procedure, collagen gradually increases, and the result is natural.

Park, T. H., Choi, W. Y., Lee, J. H., & Lee, W. J. (2017). Micronized cross-linked human acellular dermal matrices: An effective scaffold for collagen synthesis and promising material for tissue augmentation. Tissue Engineering and Regenerative Medicine, 14 (5), 517-523. doi:10.1007/s13770-017-0054-1

(2) Improvement of dry and sensitive skin (strengthening of the barrier function from the dermis)

When it comes to the barrier function that suppresses moisture evaporation inside the skin, the stratum corneum, the outermost layer of the skin, plays the leading role. However, the epidermis, including the stratum corneum, is largely dependent on the supply of moisture and nutrients from the dermis, which is the foundation of the skin.

When the ECM of the dermis is restructured by CellDiem, the moisture retention of the dermal layer is improved. The moisture and signals are then delivered firmly to the epidermis, thereby stimulating turnover.

As a result, the barrier function of the epidermis itself is raised by strong support from the inside, which is expected to improve sensitive skin that is prone to redness at the slightest provocation, chronic dryness, and the fine lines and wrinkles that accompany it.

Note that clinical studies have reported that hADM injections have shown excellent improvements in skin density, elasticity, moisture retention, and barrier function parameters.

Lee, Y. I., Chau, N. H., Nguyen, N. H., Ham, S., Baek, Y., Kim, J., & Lee, J. H. (2024). Injectable particulated human acellular dermal matrix booster for skin restoration: An integrated randomized, split-face, double-blinded clinical trial and preclinical study. International Journal of Molecular Sciences, 27 (5), 2193. doi:10.3390/ijms27052193

 (3) Improvement of pores, texture, and dullness

Because the particles of CELDIM formulation are very fine, it can be distributed evenly in the dermis.

The injected hADM and newly generated autologous tissue increase the thickness and density of the entire dermis layer. The foundation of the skin is then pushed up from the inside,Tightens pores that have widened due to gravity caused by sagging dermis.

Also,Skin surface irregularities are flattened, resulting in uniform light reflection, and a texture with a well-defined, clear, and luminous skin texture..

How long has Cerdiem been in effect?

Immediately after treatment - several days	Physical swelling and moist feeling due to formulation
3-5 days later	Improve blood circulation and stabilize skin barrier
1 to 2 weeks later	Improvement of pores, texture, fine lines and wrinkles, and start of collagen regeneration
3-4 weeks later	Improvement of dullness and firmness
1 to 2 months later	Peak effect

The effect of SERDIM is not "immediate" like hyaluronic acid injections, but rather gradual due to its nature of stimulating the production of self-collagen.

About 2 to 4 weeks after the surgery, the patient will notice gradual changes, such as "the skin tone is gradually improving" and "I noticed a decrease in fine lines and wrinkles.

Estimated duration and recommended frequency of serdiem

A continuous approach will help stabilize the skin's foundation more easily.Multiple sessions are recommended rather than "one and done" to maintain effectiveness and improve skin quality.

Note that effects may vary depending on individual differences and skin conditions.

SERDIM is recommended for

Injection amount, injection site, and injection method of SERDIM

Because the cell-diem is processed into ultrafine particles,Not only for the entire face, but also for areas with thin skin, such as around the eyesThe company is doing so.

The doctor will examine you during the consultation to determine how much you need for your skin and make a suggestion.

Differences between SERDIM and other skin boosters

We have a wide range of different formulations, and we have summarized the differences between them below.

	sendiem	Lituo.	REJURAN	hyaluronic acid
Principal component	hADM (ultrafine particles)	hADM (normal particle)	PN/PDRN	hyaluronic acid
Expected Benefits	Luminescence, texture, and barrier function support	Plumpness and firmness from the inside	Cell regeneration and inflammation improvement	Immediate volume increase
Pain	few	a little less than	somewhat strong	Normal, depending on site
How the effect is manifested	gentle	gentle	gentle	Fast-acting

 Cerdiem vs. Rituo (Re2O / Bunaju): Difference in particle size and finish

Both Seldiem and Rituo are ECM skin boosters with hADM as the main ingredient, though,The difference is the "fineness of the particles," the way they are distributed, and the design of the approach to the dermis.The following is located in the

SELDIM's hADM has ultra-fine particles of 75µm, allowing for more uniform delivery. This leads to a superior approach to "luminous" and "glow" sensations. The finer particles also make unevenness less noticeable, making the formulation easier to use around the eyes.

On the other hand, the particle size of Lituo is about 100 µm, larger than that of CELDIM, and its design focuses on the structural retention of ECM components and the restructuring of the dermal environment. As a result, it contributes to improved firmness, elasticity, and moisture retention, leading to a plump texture from within.

It is important to choose the appropriate formulation according to the purpose and current skin condition, not which is better.

Serdiem vs. Riguran: pain and points of use

Rejuran (PN formulation), synonymous with skin growth injections, is excellent for "cell regeneration at the DNA level.

However,When the ECM in the dermis is depleted due to aging, etc., and the skin is scaly, collagen cannot be produced properly because there is no "scaffold" for the cells to work even if they are "stimulated"..

What is effective there is the "physical reconstruction of the ECM" with CellDiem. Since it directly replaces the lost scaffold itself, functions as a scaffold, and supports the structure, it is ideal for the fundamental treatment of skin with a foundation so thin that Rejelan is ineffective.

Furthermore, since the ingredients are micronized, the pain at the time of injection can be significantly reduced compared to Rejelan, which is another major advantage.

CellDIM vs. Hyaluronic Acid: From "supplement" to "nurture

Hyaluronic acid injections are good at adding volume and filling in deep wrinkles in specific areas, such as laugh lines and nose heightIt is. While its effect is immediate and visually obvious, it also has the aspect of "reverting back to normal once the hyaluronic acid is absorbed.

On the other hand, SERDYM is not a localized volume enhancement, but rather an enhancement of the skin density of the entire face to bring out its natural beauty. In other words, it is a procedure that "nurtures" the skin.

More effective treatment when combined with SERDIM

Preparing the skin's foundation with CELDIM enhances the skin's response to subsequent treatments.

We can also suggest combinations with other treatments depending on your concerns and skin condition. Here are some particularly recommended combinations.

ZAF (radiofrequency)｜For tightening of sagging and face lines

Zurf is a sagging treatment that delivers radiofrequency (RF) energy from the dermis to the subcutaneous fat layer to stimulate collagen production. Receiving Zarv while the ECM foundation is reinforced with CellDiem can be expected to have a synergistic effect on collagen production.

For those who are concerned about sagging facial lines, laugh lines, and marionette linesThis combination is especially recommended.

Photofacial (IPL)｜Improvement of spots, dullness, and redness

A photofacial is a procedure that uses light called IPL (Intense Pulsed Light) to address blemishes, dullness, and redness. By enhancing the skin's density and barrier function with CellDiem and then undergoing a Photofacial, uniform penetration of light and improved skin recovery can be expected.

For those who value transparency and tone enhancementIt is a suitable combination.

Pain is reduced by ultra-fine particle technology

Because SERDIM's ingredients are processed into extremely fine particles, the needle resistance during injection is low and designed to reduce pain easily.
In addition, the use of anesthetic cream or cooling will further reduce discomfort during the procedure.

Many people feel "less pain" compared to Re2O as well as Rejuran.

Duration and symptoms of downtime

The following symptoms may occur after the cerdiem procedure.
Both are common reactions and often settle within a few days.

Because of the needle insertion, there will be general redness, mild swelling, and a burning sensation immediately after the treatment, but this usually settles down within a few hours or the next day.

In addition, because the drug is injected finely into the shallow layers of the skin, numerous small bulges (wheals) similar to mosquito bites will appear immediately after the procedure. Although it varies from person to person, please be assured that they are usually absorbed by the skin within 24 hours to a few days and return to a flat surface.

Thin skin areas such as around the eyes may rarely show internal bleeding (blue or yellowish bruising). It can be concealed with makeup, but it may take 1-2 weeks for it to disappear completely.

In both cases, the manifestation of symptoms varies from person to person.

Postoperative Care

Risk of allergy/side effects

In rare cases, the following risks may occur

CellDiem's main ingredient, hADM, has undergone a rigorous purification process to remove cellular components that cause immune reactions. It is designed to be particularly biocompatible among human-derived ingredients,Low risk of allergy or rejectionIt is considered to be a

However, no treatment has zero risk. Please be sure to inform us of your medical history and allergies during your pre-treatment counseling.

In general, downtime symptoms will diminish with time. If pain, itching, or increased redness is observed, an infection or allergic reaction may be present. Please contact the clinic promptly for treatment.

Those who need attention

Please consult your doctor in advance if you fall into any of the following categories

Those who are not eligible for the treatment

Flow of SERDIM treatment

FAQ

Does Cerdiem cause pain?

Since an anesthetic cream is used in advance and an ultrafine needle is used, there is a slight stinging pain, but it is tolerable enough. The pain is mild compared to conventional preparations such as Rejuran.

Can I receive treatment while pregnant or breastfeeding?

We do not perform the procedure on pregnant or nursing mothers. Due to insufficient safety data, please consult with us after breastfeeding has ended.

Can I donate blood after the Cerdiem procedure?

We are sorry, but you will not be able to donate blood after the procedure.
Although SERDYM is a safe product that has been rigorously processed, current Japanese Red Cross regulations restrict blood donations because it is made from human-derived tissue (hADM).

Which should I choose, Cerdiem or Lituo?

SERDIM tends to be suitable for those who are concerned about "luminescence, texture, and barrier function," while LITUO tends to be suitable for those who value "plumpness and firmness from within. For details, please consult us at a consultation.

Can SERDIM be combined with other treatments?

Possible. May have a more synergistic effect. Consult your physician for combination and timing.

Can I use makeup and wash my face immediately after the CELDIM treatment?

Please refrain from doing so for 12 hours after the treatment. The next day, you may resume your normal activities.

How many times should I take the course before I see results?

Although the effects vary from person to person, it is easier to feel the changes if you receive the treatment three times, once every three to four weeks. After that, the standard maintenance schedule is once every 3 to 6 months.

More Information

Treatment Time	Approximately 30 minutes (excluding counseling)
Recommended number and frequency of treatments	Recommended to be done in sets of three at intervals of 3 to 4 weeks. After that, maintenance is recommended every 3 to 6 months.
Down time	About 24 hours
Treatment on the day of counseling	Possible
Make	Available starting the next day
Skin care	Possible immediately after the treatment Avoid irritating substances and focus on moisturizing and UV protection.
Shower	Possible from the same day
Pain	There is a stinging pain when the needle is inserted.

*There are individual differences.

[Legal description

SERDIM includes procedures using drugs or medical devices that are not approved in Japan. The medicines and devices used in the treatment have been imported on a personal import basis under the judgment of our physicians.

Please refer to this page for information on medicines, etc. that should be noted for personal importation.
Ministry of Health, Labour and Welfare, "Medicines, etc. that Require Caution in Personal Importation".

Go to Smart Skin Clinic for SERDIM.

SELDIM (Skin Plus) is a next-generation skin booster that enhances the skin's self-renewal power, a far cry from the conventional "supplement from the outside" approach. Human-derived ECM (hADM) ingredients stimulate collagen production in the dermis, and comprehensive skin quality improvement in terms of firmness, elasticity, barrier function, and luminosity can be expected.

SERDIM is injected by hand. The doctor can adjust the needle angle, depth, and injection speed in real time, making it flexible for delicate areas such as under the eyes and around the mouth. Because Smart Skin Clinic performs over 10,000 injections per year, we are able to design the optimal injection for each area.

Please feel free to visit us for counseling. There is no pressure to come to us.

Reference

Park, T. H., Choi, W. Y., Lee, J. H., & Lee, W. J. (2017). Micronized cross-linked human acellular dermal matrices: An effective scaffold for collagen synthesis and promising material for tissue augmentation. Tissue Engineering and Regenerative Medicine, 14 (5), 517-523. doi:10.1007/s13770-017-0054-1

Lee, Y. I., Chau, N. H., Nguyen, N. H., Ham, S., Baek, Y., Kim, J., & Lee, J. H. (2024). Injectable particulated human acellular dermal matrix booster for skin restoration: An integrated randomized, split-face, double-blinded clinical trial and preclinical study. International Journal of Molecular Sciences, 27 (5), 2193. doi:10.3390/ijms27052193