Rejuran Evolution] 4 kinds of Plurials｜Smart Skin Clinic

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Hello, I am a doctor at Smart Skin Clinic, an aesthetic dermatology clinic.

Do you have any of these questions or concerns?

In this article,A detailed description of each of the four types in the Pluryal Densifier seriesour cosmetic dermatology clinic will explain in an easy-to-understand way.

Supervisor Information

Group Chief Director, Smart Skin Clinic Group

IshiiIshii KotaKota

Career

Graduated from Juntendo University School of Medicine

Worked at Tokyo Women's Medical University Hospital and affiliated facilities

Worked at a major aesthetic clinic in Tokyo

Affiliations / Qualifications

Board-certified specialist, Japan Surgical Society

Board-certified specialist, Japanese Society of Anti-Aging Medicine

What is the Pluryal (PLURYAL) Densifier series?

The Pluryal (PLURYAL) Densifier series is a new injectable formulation using the latest biostimulator technology.

Developed by MD Skin Solutions of Luxembourg,it is used in more than 20 countries, primarily across Europe,and is a product drawing considerable attention.

Pluryal comes in the following four types:

1. Pluryal Silk (PLURYAL SILK)
2. Pluryal Densify (PLURYAL DENSIFY)
3. Biosculpture (PLURYAL BIOSCULPTURE)
4. Pluryal Hair Density (PLURYAL HAIR DENSITY)

These products offer comprehensive solutions for a wide range of needs, from eye-area care to full-face anti-aging and even hair growth.

Main ingredient of the Pluryal (PLURYAL) Densifier series

This series'main ingredient of the flagship products is polynucleotide (PN),a highly purified DNA fragment derived from salmon.

PN offers the following effects:

1. Increased skin hydration
2. antioxidant action
3. anti-inflammatory action
4. Promotes fibroblast proliferation
5. DNA repair and regeneration
6. Promotion of angiogenesis

Thanks to these effects, the Pluryal (PLURYAL) Densifier series delivers more than just temporary improvement; it revitalizes the natural functions of the skin and hair for long-term improvement in quality.

Features and benefits of each product

Now, we'll explain the features and benefits of each product in detail.

1. Pluryal Silk (PLURYAL SILK)

Pluryal Silk (PLURYAL SILK)is a groundbreaking product developed specifically for the eye area.CE approved exclusively for use around the eyesso it does.

Key features:

• Effective for fine wrinkles around the eyes and mouth
• High expectations for improving dark circles
• A formulation designed to suit delicate areas

For details, seethe Pluryal Silk (PLURYAL SILK) articlePlease see it.

2. Pluryal Densify (PLURYAL DENSIFY)

Pluryal Densify (PLURYAL DENSIFY)isSpecialized in improving the skin quality of the entire facea product that is

Key features:

• Non-cross-linked hyaluronic acid added to PN andMannitolblended in a proprietary way
• Whole-face skin-quality improvement is possible
• Effective for improving firmness and radiance

For details,the Pluryal Densify (PLURYAL DENSIFY) articleexplains it.

3. Biosculpture (PLURYAL BIOSCULPTURE)

Biosculpture (PLURYAL BIOSCULPTURE)is a product that promotes multidimensional anti-aging.

Key features:

• A special blend of three types of hyaluronic acid
• Facial contouring effect
• moreDeep wrinkles and saggingAddresses

For details,The Pluryal Biosculpture (PLURYAL BIOSCULPTURE) articleexplains it.

4. Pluryal Hair Density (PLURYAL HAIR DENSITY)

Pluryal Hair Density (PLURYAL HAIR DENSITY)isSpecialized in hair growtha product that is

Key features:

• Can be used on the scalp, eyebrows, and beard
• Effective for male pattern hair loss (AGA) and female pattern hair loss (FAGA)
• Supports hair growth and increases hair thickness

For more information,the Pluryal Hair Density (PLURYAL HAIR DENSITY) articleplease check it out.

The difference between Pluryal and Rejuran: an accurate comparison and how to choose

A question we receive from many people"the difference between Pluryal and Rejuran"is what we'll explain here.

1. The difference in main ingredient and purity

Both formulationshave polynucleotide (PN) as their main ingredient,but there is a significant difference.

• Pluryal:
  • Proteins are completely removed, making the PN purity extremely high.
  • The allergy risk is very low.
• Rejuran:
  • A certain amount of protein remains.
  • The allergy risk is slightly higher compared with Pluryal.

2. Comparison of product lineups

Both formulations come in several products, but their characteristics differ.

Pluryal:

1. Pluryal Silk: exclusively for the eye area
2. Pluryal Densify: for the whole face
3. Pluryal Biosculpture: for multidimensional anti-aging
4. Pluryal Hair Density: for hair growth

Rejuran:

1. Rejuran I: for the eye area
2. Rejuran S: for acne scars
3. Rejuran Healer: for the whole face
4. Rejuran HB: enhanced moisturizing effect, reduced-pain type

Pluryal is distinctive in that the use of each product is more clearly defined, and in particular it includes a product dedicated to multidimensional anti-aging (Biosculpture). Rejuran HB, on the other hand, is known as a product with enhanced moisturizing properties.

3. The difference in effect

• Pluryal:
  • Good balance of immediate and lasting effects
  • Strong multidimensional anti-aging effect
  • In addition to improving skin quality, improvement of the contours can also be expected
• Rejuran:
  • The effect emerges gradually
  • Highly effective at improving skin quality
  • Particularly effective at improving acne scars

*However, since there are four types of each, the characteristics and effects differ for each formulation.

4. The difference in indications

• Pluryal:
  • Eye care
  • Full-face anti-aging
  • Improvement of facial contours
  • Hair growth
• Rejuran:
  • Improvement of skin quality across the whole face
  • Improvement of acne scars
  • Pore tightening
  • Enhanced moisturizing effect, reduced pain (especially HB)

5. Cost comparison

In general, Rejuran tends to cost more than Pluryal.However, specific prices vary by product, procedure, and clinic, so please check with each clinic for details.

6. How to choose: which one should you pick?

The following criteria may help you choose the right one.

When you should choose Pluryal:

• Those with concerns about allergies
• Those seeking more immediate results
• Those who also wish to improve facial contours at the same time
• Those who want treatment specialized in eye-area care
• Those who would also like to expect hair-growth benefits
• Those who want to keep costs somewhat lower

When you should choose Rejuran:

• Those who want to take their time improving their skin quality
• Those whose main goal is to improve acne scars
• Those who prioritize pore tightening
• Those seeking a particularly moisturizing effect (Rejuran HB)
• Those who prefer a formulation with a long track record

Summary

Both Pluryal and Rejuran are excellent formulations, but there are clear differences in their characteristics and effects. Pluryal allows a more multifaceted approach and is characterized by a good balance between immediate and lasting effects. Rejuran, on the other hand, specializes in improving skin quality and works steadily over time.

The best choice varies depending on your skin condition and concerns, the results you expect, and your budget. Please use this as a reference and choose the formulation best for you through a consultation at the clinic.

Advantages of the Pluryal (PLURYAL) Densifier series

The Pluryal series offers many advantages. Here are some of the main ones.

1. A comprehensive approach: It can address a wide range of concerns, from the eyes to the whole face and even the scalp.
2. Natural finish: It promotes the body's natural regeneration process, so there is nothing unnatural about the result.
3. Long-term effects: Beyond temporary improvement, the effect emerges gradually with continued use.
4. Low risk: Because highly purified ingredients are used, the allergy risk is low.
5. Customizable: The best product can be selected to match each person's concerns.

Features of Smart Skin Clinic’s Plural | Our ”Commitment“ to Injectable Formulations“

Following our director's philosophy, we perform injections with the following "attention to detail."

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Why Choose Our Clinic? | Over 24,000 Injections Per Year and Proven Expertise

Injection technique backed by case volume

At Smart Skin Clinic, we perform over 24,000 injection procedures annually.

With skilled assessment and injection technique, we carefully deliver custom-tailored treatment—identifying the right points, reaching the precise layer, and using the appropriate dosage. Using carefully sourced "medical injection needles" and refined technique, we keep swelling and bruising to a minimum.

One of the largest formulation ranges in Japan

Our clinic keeps more than 35 types of injectables in stock at all times, including PN formulations, skin-nurturing formulations, and collagen boosters. We are here to help those who aren't sure which product to choose, or who would like a diagnosis tailored to their concerns.

Bruising rate of 0.5% or less

Thanks to our "carefully chosen needles" and "injection technique," our bruising rate has remained 0.5% or less.

Smart Skin Clinic Pricing

Silk (manual injection by a physician)

Densify (Water Light Injection treatment)

Hair Density (Water Light Injection treatment)

Our clinic is the firstReasons for our popularity

[Official] Smart Skin Clinic...

Why Smart Skin Clinic Is "So Popular It's Hard to Get an Appointment" | [Smart Skin Clinic Group...]. Smart Skin Clinic consistently earns high ratings in reviews on Google, Hot Pepper, Kirei Pass, and more. We at Smart Skin Clinic think carefully about what you truly need...

Frequently Asked Questions (FAQ)

Q1: Which product should I choose?

A: The best product varies according to each person's concerns and goals. For example, for eye-area care,Pluryal Silkfor full-face skin-quality improvement,Pluryal Densifyand for hair growth,Pluryal Hair Densityis recommended. For details, please see each product's article or consult us during counseling.

Q2: When can I expect to notice results?

A: It varies by product and individual, but in general you'll gradually begin to feel the effect after 2-4 weeks, with the maximum effect appearing after 2-3 months. The effect continues with ongoing use.

Q3: Are there any side effects?

A: The Pluryal (PLURYAL) Densifier series has very few side effects. In rare cases, temporary redness or swelling at the injection site may occur, but this usually improves naturally within a few days.

Q4: Can it be combined with other cosmetic treatments?

A: Yes, it can be combined with many cosmetic treatments. However, in some cases appropriate spacing between treatments may be required.

Summary: Why the Pluryal (PLURYAL) Densifier series is chosen

The Pluryal (PLURYAL) Densifier series offers a variety of advantages.

1. Wide-ranging coverage: It can address a variety of concerns—the eyes, the whole face, and the scalp.
2. Natural finish: Because it enhances the natural functions of the skin and hair, there is nothing unnatural about the result.
3. Long-term effects: You can expect not only immediate effects but also long-term improvement in quality.

For details, please also see each product's article (Pluryal Silk,Pluryal Densify,Pluryal Biosculpture,Pluryal Hair Density).

Restore your own unique beauty with the Pluryal (PLURYAL) Densifier series! Please feel free to visit our clinic for a consultation.

CLINIC LIST

Clinic List

Jimbocho Clinic

〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F

Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00

Yokohama Clinic

〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa

Hours: 10:00–19:00

Reference (clinical evidence)

Lim, T. S., Liew, S., Tee, X. J., Chong, I., Lo, F. J., Ho, M. J., Ong, K. T., & Cavallini, M. (2024). Polynucleotides HPT for Asian skin regeneration and rejuvenation. Clinical, Cosmetic and Investigational Dermatology, 17, 417-431. doi:10.2147/CCID.S437942

Lee, Y. J., Kim, H. T., Lee, Y. J., Paik, S. H., Moon, Y. S., Lee, W. J., Chang, S. E., Lee, M. W., Choi, J. H., Jung, J. M., & Won, C. H. (2022). Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: A randomized, double-blind, split-face trial. Journal of Dermatological Treatment, 33(1), 254-260. doi:10.1080/09546634.2020.1748857

Eliana, F., Cavallini, M., et al. (2026). A real-life assessment of injectable polynucleotides high purification technology in aesthetic medicine for skin rejuvenation. Journal of Cosmetic Dermatology, 25(1), e70532. doi:10.1111/jocd.70532