What are dermapen agents and induction solutions? 22 types of characteristics and recommendations are explained.

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Should I also use the drug when I get the dermapen?"

I've heard the term "dermapen drug," but what exactly is a dermapen drug?"

What kinds of drugs are there and what are their characteristics?"

Hello, I am a doctor at Smart Skin Clinic.

Are you wondering about getting a dermapen and have these concerns or questions?

There is so much information floating around that it is hard to know what is true.

In this article, Smart Skin Clinic, a cosmetic dermatology clinic, will address these questions from a medical perspective in an easy-to-understand manner.

This article has also been carefully compiled by the doctors themselves, while doing their own research. And please rest assured that this information should be unique on the Internet in that it is a comprehensive and in-depth summary of "Dermapen Drugs".


What is a dermapen drug?

The dermapen is simply put,Treatment for beautiful skin by "making small holes in the skin" to promote skin regeneration.will be.

Under normal conditions, however, the skin is unable to allow substances to penetrate into the skin,After the dermapen procedure, the substance can enter the skin through the small holes created.

Diagram explaining how the dermapen works

(Source: Prepared by Smart Skin Clinic)

This is used in "induction therapy," that is, to put the drug deep into the skin.

The drug goes deep into the skin where it normally cannot enter,It has a variety of effects from deep within the skin.This effect depends on the drug to be introduced. I will explain how the effect of each drug differs in the following sections.

Depending on how you think about it, it would be more "affordable" to put a drug in your skin since you are going to make a hole in it (laughs).

Also, there is a big difference in the drugs employed by different clinics,

What kind of drugs are available?

What is the difference between them?

This section will explain this point in detail.

When I get a dermapen, should I also use drugs?

Although the drug is used in the dermapen procedure, it is not required to be used.

Again, to begin with, the Dermapen is a treatment that stimulates skin regeneration through its natural ability to heal wounds.
Therefore, even without the use of drugs, fibroblast cells that control skin firmness and elasticity are activated in the process of skin regeneration, and problems such as open pores, acne scars, fine lines and wrinkles, firmness, and luster can be approached.

Nevertheless, the reason why the use of the drug is recommended at the same time as the dermapen procedure,This is because it has the great advantage of directly penetrating and acting on active ingredients deep into the skin, which would normally be difficult to deliver.It is.

It takes time for these skin problems to be resolved with the dermapen alone.
The use of drugs can quickly improve skin problems, and the synergistic effect of the dermapen and drugs can bring about more beautiful skin.

I highly recommend the combination of dermapen and drug.

Types and Characteristics of Drugs

There are a variety of dermapen agents available. Here is a typicaldrug22(biological) speciesThe following is a description of the characteristics of the

This is a long page, so if you want to know about effective agents for different purposes, please skip to the next page.

Antioxidant cocktail (official drug of Dermapen)

[Main ingredients: antioxidant substances, serums].

  • A mix of powerful antioxidant substances and beauty ingredients such as vitamins C and B3, Argireline & Synchol, Rooibos & Aloe Vera!
  • Prevents and improves wrinkles, spots, and sagging, revives skin elasticity and firmness, and reduces dryness and inflammation

CLR lotion (official drug of Dermapen)

Main ingredients: natural factor (NMF) amino acids, manuka honey, vegetable salicylic acid, etc.

  • Contains niacinamide and salicylic acid, important for acne care
  • Removes dirt and excess dead skin cells from pores that cause acne
  • Reduces excess oil secretion and controls moisture content, thereby simultaneously treating acne and moisturizing the skin
  • It is effective against existing acne and acne scars, and leads to acne-resistant skin.

Weber Peel (official drug of Dermapen)

Peeling agent

  • This all-in-one hypoallergenic peeling agent contains more than 10 ingredients.
  • By increasing skin cell metabolism and activating turnover, dead skin cells on the skin surface are removed. It is effective for pigmentation, spots, melasma, etc., and also improves acne-prone skin.
  • Because the needle depth during the procedure is shallow, there is relatively little bleeding and pain, and downtime is short.

HylaActive (official drug of Dermapen)

Main ingredients: highly concentrated hyaluronic acid, zinc, vitamin B5, etc.

  • It is expected to moisturize and improve skin elasticity, and reduce the side effects of dermapen treatment, such as facial redness, pain, itching, and swelling.
  • Hylactiv by itself is effective, but when used in combination with other drugs for supplementary purposes, a synergistic cosmetic effect can be expected.

BrightLight (official drug of Dermapen)

Main ingredients: kojic acid, vitamin C, and kanzo root.

  • Contains agents that inhibit melanin production and collagen production
  • It helps to even out uneven skin tone, improve dullness, spots, melasma, and sunburn, and improve skin elasticity.

Exosome (official drug of Dermapen)

Main ingredients: Human adipose stem cell culture fluid

  • Exosomes are intercellular signaling molecules secreted by cells. It is extracted from "stem cell culture supernatant fluid," which is the filtered supernatant fluid of "stem cell culture fluid" used in regenerative medicine.
  • Exosomes contain numerous growth factors, anti-inflammatory cytokines, and bioactive substances involved in tissue repair and immunomodulation.
  • Skin cell repair and regeneration is promoted by exosomes. It is effective in treating wrinkles, sagging skin, and acne scars, and is expected to restore a firm, healthy, youthful appearance
  • It also has anti-inflammatory properties, so it is effective for atopic dermatitis and hyperpigmentation associated with atopic dermatitis
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Velvet skin (PRX-T33)

Peeling agent

  • When used together with a dermapen, the effects can be delivered deep into the skin, synergistically increasing the cosmetic effect. The combination of Dermapen and PRX-T33 is called "Velvet Skin". Velvet is the name of a beautiful fabric, meaning that one can achieve such beautiful skin.
  • PRX-T33 contains three beauty ingredients (TCA (trichloroacetic acid), hydrogen peroxide, and kojic acid). These ingredients give elasticity and firmness to the skin, suppress melanin production, and lead to skin whitening!
  • This is one of the most popular drugs used with dermapen!
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vitamin C

  • Vitamin C has powerful antioxidant properties and promotes collagen production
  • Not only does it whiten existing spots and freckles, but it also prevents new spots and freckles
  • Collagen production is stimulated, which helps to restore elasticity and firmness to the skin and improve wrinkles and sagging skin.

tranexamic acid

  • Tranexamic acid indirectly suppresses melanin production by reducing skin inflammation and irritation that trigger melanin production
  • It also reduces inflammation, which helps to reduce roughness and redness and maintain healthy skin conditions


Main ingredients: Highly concentrated hyaluronic acid, serum

  • Drugs containing highly concentrated hyaluronic acid, 54 types of amino acids, vitamins, and other beauty solutions
  • Hyaluronic acid and cosmetic ingredients moisturize the skin and restore its firmness and luster. In addition, fine lines and wrinkles will become less noticeable.

Collagen booster (PCL)

Main ingredient: PCL (polycaprolactone)

  • PCL is a drug that promotes collagen production
  • The penetrating agent is slowly absorbed into the skin, and the effect of collagen production lasts for a long time. Therefore, wrinkles and improvement of skin elasticity and firmness can be expected for a long time.


Main ingredient: botulinum toxin type A

  • Botulinum toxin type A is a neurotoxin and a type of neurotoxin. It blocks the signals from the nerves that regulate muscle contraction, thus primary inhibiting muscle movement.
  • When Botox is penetrated into the shallow areas of the skin with a dermapen, wrinkles that are primary to the skin surface are less likely to occur. Wrinkles are expected to improve as fine lines and wrinkles caused by facial expressions are no longer fixed
  • The activity of sebaceous and sweat glands is suppressed, which reduces sebum secretion and prevents acne.


Main ingredient: acetyl hexapeptide-3 (fragment of botulinum toxin substrate)

  • Acetyl hexapeptide-3 is a synthetic peptide (amino acid) derived from plants
  • A peptide ingredient that produces an effect similar to Botox, but does not inhibit muscle movement as well as Botox injections, also known as Botox applied
  • Usually used as an ingredient in skin care products, but when combined with a dermapen, it penetrates deeper into the skin and enhances its effect
  • It is effective for light fine lines and wrinkles and mild sagging caused by facial muscles, and also suppresses sebum secretion and tightens pores.


Main ingredients: non-cross-linked hyaluronic acid, six amino acids

  • It is a non-cross-linked form, the same as hyaluronic acid found in the human body, so it retains water while moving freely. (In contrast, "cross-linked hyaluronic acid" is a gel-like substance with chemical bonds between hyaluronic acid molecules. It is used for the purpose of improving wrinkles and sagging.)
  • Unlike cross-linked hyaluronic acid, it does not swell, so fine lines and wrinkles around the eyes, mouth, and neck are improved in a natural way.
  • Six types of amino acids stimulate fibroblasts (cells that produce cells necessary for skin elasticity), which restores elasticity and firmness to the skin.
  • When used under the eye, it is expected to improve blue and dark circles by increasing the thickness of the skin.
  • It can provide extensive moisturizing and improve skin texture, but it may take some time before you feel its effects.


Main ingredients: growth factors, highly concentrated hyaluronic acid, beauty ingredients

  • Drugs containing 8 types of growth factors, highly concentrated hyaluronic acid, and 33 types of cosmetic ingredients
  • The effect of growth factors in repairing skin cells and promoting their production activates skin turnover and improves craters, acne scars, and hyperpigmentation.


Main ingredient: umbilical cord blood stem cell culture fluid

  • Drugs containing hundreds of growth factors cultured from stem cells in the blood derived from the umbilical cord of babies
  • It is expected to promote skin cell repair and production, and the associated activation of skin turnover.
  • Babyskin improves wrinkles, spots, craters, acne scars, and hyperpigmentation

amnio genics

Main ingredients:: Human placental derivatives (dried amniotic membrane/chorionic villus membrane)

  • Dry amnion or chorioallantoic membrane is the egg membrane (the membrane that surrounds the baby in the belly)
  • Contains 285 ingredients including growth factors, cytokines, collagen, etc.
  • Skin metabolism is activated and skin regeneration and cell proliferation are promoted
  • Effective for acne scars, craters, wrinkles, spots, sagging, scars, etc.

    *After using AmnioGenics, you will not be able to donate blood.


Main ingredient: PDRN (polydeoxynucleotide), a growth factor derived from salmon.

  • PDRN is close to the human body's DNA and is also called salmon injection because it is extracted from salmon DNA
  • Growth factors increase the skin's ability to regenerate, which improves acne scars and increases elasticity and firmness, thereby reducing pores and fine lines and wrinkles.
  • When new capillaries are created by the angiogenesis effect of growth factors, blood flow improves and redness of the face improves.

Bright/MPF Rejuvenating Complex

Main ingredients: Human fibroblast culture fluid

  • In addition to the main ingredients, it contains other cosmetic ingredients including growth factors, vitamins and hyaluronic acid
  • Growth factors promote the regeneration and proliferation of skin cells, which helps to improve acne scars, craters, and wrinkles, and leads to more elastic and resilient skin.
  • Also, many beauty ingredients can be absorbed together to improve the skin texture to moisturize and brighten the skin.

SRS Mask Pack Cell Fit Pure

Main ingredient: human umbilical cord blood stem cell culture medium

  • It is a medical pack that contains growth factors in addition to the main ingredients.
  • It can also be used for supplementary purposes as home care after a dermapen procedure. In this case, it is recommended when you want to recover quickly from the damage, as it has cooling and moisturizing effects on symptoms such as facial redness, pain, itching, and swelling caused by the dermapen procedure.
  • When used in combination with other Dermapen agents, the skin beautifying ingredients penetrate deeper
  • Used alone, it can improve acne scars, wrinkles, firmness, etc.


Main ingredient: red deer umbilical cord stem cell culture fluid

  • In addition to the main ingredients, it contains several other cosmetic ingredients. The culture medium contains two types of stem cells
  • Stem cells are rich in growth factors and cytokines that are necessary for skin repair and regeneration, and the cells themselves, deep within the skin, self-renew!
  • Skin elasticity and firmness are improved, leading to a youthful, fine-grained, bright skin.

premium cell

Main ingredient: Human bone marrow stem cell culture fluid

  • Secretes many growth factors
  • It has a high ability to repair and regenerate surrounding tissues and also activates cells necessary for skin elasticity and firmness, so anti-aging effects, especially wrinkles and firmness, can be expected.
  • A growth factor, TGFB also regulates melanin production. It has a whitening effect that even out skin tone and maintains a bright skin tone

Recommended drugs by problem/purpose

Here I will explain which drug to choose for each problem and expected effect.I want to know which dermapen drug is right for me."If so, please read this section carefully.

If you would like to know more about the drugs listed, please go back to the previous page and read it.

Improve fine lines and sagging skin for a firmer, more resilient skin

Key to choosing an effective agent to improve "fine lines" and "sagging" skin

Contains ingredients such as hyaluronic acid and amino acids that can be expected to moisturize and improve skin elasticity

Contains ingredients that can help regenerate and repair the skin, such as growth factors and stem cell-derived

  • If you are looking for a cost-effective solution... Filorga
  • Natural Rejuvenation...Snekos
  • If you want it to last... Collagen Booster

Brighten and whiten skin tone by improving "spots" and "pigmentation".

Key to choosing effective agents to improve "spots" or "hyperpigmentation."

Contains antioxidants and ingredients that inhibit melanin production, such as vitamin C, tranexamic acid, and kojic acid

Contains ingredients that activate turnover, such as growth factors and stem cell-derived products (which promote the elimination of already existing spots)

  • If prophylactic... vitamin C and tranexamic acid.
  • If you are looking for a single drug and cosmetics... Bright Light
  • If you are looking for a whitening effect in addition to the use of other agents... Hylactiv
  • If you really want to whiten your skin... Bright/MPF Rejuvenating Complex

Improve pores that cause acne and acne scars, and achieve smooth, even skin.

The key to choosing an effective drug to improve "acne-causing pores" and "acne scars."

Contains ingredients that can control oil content and remove dirt and dead skin cells from pores

Contains ingredients that can help regenerate and repair the skin, such as growth factors and stem cell-derived

  • For oil control and acne prevention purposes...CLR lotion, Botox
  • If you want to activate turnover and improve acne scars... Uber Peel, Beneve, Amniogenic.

For those who expect anti-aging effects for various problems associated with aging

Key Points for Selecting Agents with Anti-Aging Effects

If you have multiple skin problems and want to obtain results as quickly as possible, it is effective to choose ingredients that contain growth factors or stem cell derivatives. If the drug also contains a serum, it will be even more effective.

However, growth factors and stem cell-derived products are often priced higher. Since regular treatment is necessary to maintain the anti-aging effect, it is also important to consider whether the price range is affordable to continue.

  • Exosome
  • Kalesim.
  • premium cell
  • Bright/MPF Rejuvenating Complex

Dermapen for the first time For those who want to try it casually

If you want to try out a dermapen to see what it is like, or if you want to make your skin a little more beautiful, but not so much that it is a problem, then this is the pointer to choose the right drug for you.

Anything that reduces side effects (facial redness, pain, itching, etc.) caused by dermapen.

As an addition to regular home care, moisturizing, whitening, and prevention of acne, spots, and freckles.

  • If you expect to reduce side effects... Hylactiv, SRS Mask Pack Cellfit Pure
  • If you are looking for a cost-effective solution... Velvetskin
  • For prevention of wrinkles, spots, and sagging, and for main moisturizing... Antioxidant cocktail, Hylactiv
  • For acne prevention...CLR lotion, Uber Peel
  • If you expect whitening, prevention of spots and freckles... Bright Light, Vitamin C, Tranexamic acid

For those who suffer from recurring skin problems Drugs that can be expected to improve skin quality

Point to choose a drug that can improve skin texture from the root rather than anti-aging, with repeated pigmentation due to atopic or acne inflammation.

For those who suffer from frequent hyperpigmentation due to inflammation or have problematic skin texture itself, it is effective to select agents that contain anti-inflammatory ingredients or ingredients that promote self-repair and self-growth of the skin cells themselves.

  • Exosome
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On this page, I have explained effective agents by problem/purpose and the key points for selecting agents.

The clinic you are considering for the procedure does not necessarily have the same drugs as those listed here. According to my research, the average types of dermapen agents held by cosmetic clinics areAbout 5 kindswill be.

If you are not sure which one to choose, you should consult your doctor to help you select the right drug for you.

Smart Skin Clinic Dermapen Drugs

7 types of dermapen formula drug included

Smart Skin Clinic Drug List

Reliable Dermapen drugs

Official Dermapen Pharmaceuticals, Inc.

Highly effective exosomes proven in papers

The effectiveness of Dermapen x Exosome Introductory Solution has been proven in a paper.

As for the content of the paper,"A comparative study of a solution containing human adipose tissue stem cell-derived exosomes (HACS) in combination with microneedles (dermapen) in patients with aging skin."The company is conducting the following activities.

Simply put, "Exosomes (HACS) were applied to one side of the same person's face, while saline was applied to the opposite side,Comparison of wrinkles, elasticity, moisture, and pigmentationThe first time I did this, I was in the middle of a project,There was significant improvement on the exosome (HACS) side.The results show that

The Global Aesthetic Improvement Scale score was significantly higher on the HACS-treated side than on the control side at the final follow-up visit (p = 0 .005). Objective measurements obtained by different devices including PRIMOS Premium, Cutometer MPA 580, Corneometer CM 825, and Mark-Vu confirmed greater Objective measurements obtained by different devices including PRIMOS Premium, Cutometer MPA 580, Corneometer CM 825, and Mark-Vu confirmed greater clinical improvements in skin wrinkles, elasticity, hydration, and pigmentation on the HACS-treated side than on the control side. The results of the histopathological evaluation were consistent with the clinical findings.

(Global Aesthetic Improvement Scale scores were significantly higher on the treated side of the solution containing human adipose tissue stem cell-derived exosomes than on the control side (p = 0.005). CM 825, and Mark-Vu confirmed a clinically significant improvement in skin wrinkling, elasticity, moisture, and pigmentation on the HACS treated side over the control side. Results of histopathological evaluation were consistent with clinical findings. No serious adverse events were observed.

Gyeong-Hun Park, Hyuck Hoon Kwon, Joon Seok, Steven Hoseong Yang, Joon Lee, Byung Chul Park, Eun Shin, Kui Young Park." Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging": A 12-week Journal of cosmetic dermatology. 2023 Jun 28; doi: 10.1111/jocd.15872.

Hello Orange Media has also introduced us!

Our clinic's Dermapen x Exosome treatment has been introduced by "Hello Orange Media," a website that provides information to users of cosmetic medicine.

We have received a description that includes comparisons with other clinics.

Hello Orange Media
For Dermapen 4 x Exosome introduction treatment in Tokyo! Explanation of cheap and recommended cosmetic dermatology Dermapen4 is expected to be effective for a wide range of skin problems such as acne scars, pores, and skin elasticity by enhancing the skin's ability to regenerate. It is popular as a skin regenera...

If you are not sure which dermapen drug is right for you, please feel free to contact Smart Skin Clinic. If you are not sure which dermapen is right for you, please feel free to contact us at Smart Skin Clinic.

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