exosome nasal spray therapy
*The initial price applies to first-time customers who purchase this product at our clinic.
I know what an exosome infusion is, but what is a nasal drip?" What's the difference?"
I'd like to get exosome nasal drip, but I'm not sure where to go."
Do you have any of these questions or concerns?
Exosome is a well-known anti-aging treatment, and there are various methods of administering it, including intravenous infusion and injection into the face. Among these methods is the "nasal drip," which is administered through the nose,Ministry of Health, Labour and WelfareThe following is an easy-to-understand explanation from a professional standpoint by a cosmetic dermatology clinic that is a member of the "Aesthetic Dermatology Clinic".
(* Type II and Type III Regenerative Medicine Provisioning Plans Accreditation Number: NA8230001)
*If you are comparing clinics and are concerned about fees, you may save time by jumping to the table of contents below.
What is Exosome Nasal Drops?
The procedure involves "nasal administration" of exosomes, which have anti-aging properties.
IV infusion and dermapen are perhaps the more well-known methods of administering exosomes.
Intranasal administration can deliver exosomes to the brain, preventing dementia, improving concentration, and improving brain fatigue.
What is an exosome?
Exosomes are substances originally found in the body. In medical terms, they are small cellular vesicles encased in a lipid bilayer membrane that are actively secreted by various cells and play an important role in intercellular communication.
Through this role of intercellular communication, exosomes exert diverse effects, including anti-apoptotic, anti-inflammatory, neurogenic, and angiogenic effects. As a result of exerting these effects, they provide so-called anti-aging effects.
Variations of exosome injection methods
Exosome injection methods can be broadly divided into two patterns: systemic and local administration.
systemic administration
- intravenous drip
- injection
- nasal drip
For more information on intravenous administration, click here.
local administration
- Vital Injector
- dermapen
For more information on dermapen dosing, click here.
Effect
- Dementia Prevention
- Improvement of brain fatigue
- Improvement of insomnia
- Improved concentration
- allergic rhinitis
- Improvement of post-corona sequelae
*Expected effects
*There are individual differences.
To deliver certain substances to the brain, they must pass through a barrier called the BBB.
BBB is a medical term and stands for Blood Brain Barrier, which in Japanese is the cerebrovascular barrier.
To overcome this hurdle barrier, nasal administration has gained attention as a non-invasive (damage-free) and effective route to get drugs to the central nervous system (brain).
Numerous studies have confirmed that intranasal (intranasal) administration can bypass the BBB and deliver low molecular weight substances and high molecular weight proteins to the central nervous system (brain).
Nasal administration has the advantages of noninvasiveness and high utility. Intranasal administration facilitates the delivery of all types of drug molecules and stem cells to bypass the BBB and reach the CNS, providing a non-invasive and effective method for stem cell therapy in CNS diseases.
Yu-Ting Zhang, et al. Advances in intranasal application of stem cells in the treatment of central nervous system diseases. volume 12, Article number: 210 (2021) .
Effectiveness of Nasal Nasal Therapy in Patients with Alzheimer's Disease
Data are available on nasal drip therapy for patients with Alzheimer's disease.
By using exosomes, remarkable improvement was seen in refractory diseases such as Alzheimer's disease, cerebral infarction, atopic dermatitis, rheumatoid arthritis, and pollinosis.
Without the need for expensive "transplant" surgery,It can be treated only by intravenous infusion, application as a topical drug, or inhalation through the nose.
This innovative technology is the subject of a large-scale clinical collaboration with the University of Bergen, Norway, beginning in 2019.
Minoru Ueda, "Threatening Regenerative Medicine: What is Cultured Supernatant?
Advantages/Disadvantages of nasal drops
Advantages
Administering through the nose allows the exosomes to reach the brain.
The blood vessels that go to the brain have a barrier called the BBB (blood-brain barrier) that allows only certain components to go to the brain. Therefore, in the case of intravenous administration, it is not possible to efficiently deliver the ingredients to the brain.
On the other hand, as mentioned earlier, nasal administration of exosomes (intranasal administration) allows them to reach the brain directly while bypassing the blood-brain barrier.
Demerit
One disadvantage would be that it would be costly.
Risks and Side Effects
It is basically the same as an exosome infusion. Unlike an intravenous drip, no needles are inserted, so there are no side effects from needle insertion.
Safety Initiatives｜Compliance with the Guidance of the Japanese Society for Regenerative Medicine
Our exosome infusion therapy is performed in accordance with "Guidance on the Clinical Application of Extracellular Vesicles, etc. (1st Edition)" released on April 30, 2024, by the Japanese Society for Regenerative Medicine.
This guidance is an important guide to ensure the safety and efficacy of exosome therapy, and our guidance-based rigorous quality control and safety efforts.
Specific Efforts to Ensure Safety at the Hospital
- Conduct risk profiling
- Potential risks associated with treatment are identified and appropriate measures are taken.
- Rigorous preparation process and quality control
- Our manufacturing process and quality checks are based on the latest scientific findings.
- Implementation of appropriate effectiveness verification
- We continually evaluate the effectiveness of treatments and provide the best possible treatment for our clients.
Your safety is our first priority, and we promise to provide treatment based on the latest scientific findings.
How to use nasal drops (Instructions for use)
Features of Smart Skin Clinic's Exosome Nasal Drop Therapy
Use of umbilical cord-derived exosomes
SmartSkin Clinic uses exosomes derived from the umbilical cord, which are one of the three major types of exosomes: (1) umbilical cord-derived, (2) fat-derived, and (3) pulp/marrow-derived.
When compared to other exosomes, umbilical cord-derived exosomes contain 14 times more effective components, as shown in the figure below.
We will also introduce two of these "active ingredients," including specific data.
(1) Rich in active ingredients for skin
The first is data on the active ingredients for "skin".
Exosomes have various anti-aging effects, one of which is the effect on "skin. As shown in the figure below, umbilical cord-derived exosomes contain more active ingredients for skin than other exosomes.
(2) Rich in rejuvenating protein "GDF-11
The second will be data on ingredients involved in "rejuvenation.
There is a component called GDF-11, which is involved in rejuvenation, and is abundant in umbilical cord-derived exosomes, as shown by the following data.
Commitment to price and quality
We are committed to price and quality. In order to realize this commitment, we are implementing various initiatives. We are implementing various cost-cutting measures (e.g., less glamorous interior design, elimination of receptionists to reduce labor costs, etc.).
For more information, please click here.
In accordance with MISEV2018, Minimal Information for Studies of Extracellular Vesicles (MISEV) 2018
In exosomes, extraction methods, exosome size, storage methods and shapes vary.
For this reason, the International Society for the Study of the Endoplasmic Reticulum (ISEV) has established guidelines for the standardization of exosome protocols.
The guidelines proposed by ISEV will be the Minimal Information for Studies of Extracellular Vesicles (MISEV) 2018 Edition.
We perform extraction and purification in accordance with misev2018 at our cell culture and processing facility, which is then used at our hospital.The Company has been working on the following
Charge
| 5cc per bottle [for one week]. | |
|---|---|
| Initial Price | 29,440 yen |
| one (object) | 36,800 yen |
| Set of 2 bottles (for 2 weeks) | 71,600 yen (35,800 yen per bottle) |
| Set of 4 bottles (1 month's supply) | 131,200 yen (per bottle)32,800 yen) |
| Set of 12 (3-month supply) | 345,600 yen (per bottle)28,800 yen) |
Smart Skin Clinic
Smart Skin Clinic
The concept of the clinic is to "make cosmetic medicine more accessible and smart. is the concept of the clinic.
Instead of eliminating ornate interiors to reduce interior design costs and installing equipment in the dark, we carefully select the equipment we need and reduce the cost of the equipment.
We aim to "make cosmetic medicine more accessible" for you.
Address: 8F EX Kanda Nishiki-cho Building, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic Dermatology (aesthetic dermatology, medical hair removal, medical slimming)
Address: 8F EX Kanda Nishiki-cho Building, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic Dermatology (aesthetic dermatology, medical hair removal, medical slimming)
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of the Smart Skin Clinic supervising physicians.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.