Chiara Reju x Hydrophotonic Injection (Rejuran Generic)

Chiara Reju Hydrophotonic Injection Eye Catch

What's Chiaralleju? How does it work?"

What about pain and downtime?"

How is Chiara Reju different from Rejran?"

Do you have any of these questions or concerns about Chiaralleju?

Hello. I am a doctor at Smart Skin Clinic, a cosmetic dermatology clinic.

You may not have heard of Chiara Reju, but you may have heard of Rejuran.

This chiarallege isGeneric for Ridjulan."You can think of it as a "polynucleotide (PDRN). Rejuran is an injectable drug mainly composed of polynucleotides (PDRN), an ingredient extracted from salmon, and Chiara Rejuvenation is also an injectable drug mainly composed of polynucleotides (PDRN).

This article will explain in simple terms what Kiaralleju is, its mechanism, effects and risks.
*If you want to know the rates quickly, you can jump to the table of contents below.


What is Chiara Rejuvenation Hydroxyapatite Injection?

Kiara Reju Suikoh Injection is a skin growth treatment that cleanses the skin from the inside out by injecting a preparation called "Kiara Reju" with a device called "Suikoh Injection".

What is Chiara Leju?

Kiara Reju is a formulation whose main ingredient is polydeoxynucleotide (PDRN) derived from salmon. In addition to PDRN, Kiara Reju contains hyaluronic acid and niacinamide, and is also called a "skin booster" because it boosts the skin's own natural strength. It is also sometimes described as a "salmon injection" because it utilizes polydeoxynucleotides derived from salmon.

When you hear the words "polideoxynucleotides derived from salmon," you may think of Rejuran, which is known for its cell-regeneration effects. They may also feel uneasy about the fact that it is cheaper than Rejuran.


Rejuran is a formulation containing polydeoxynucleotides (PDRN), which are extracted from salmon DNA, as the active ingredient, and has the effect of enhancing the skin's self-regenerating ability.

Polydeoxynucleotides (PDRN) have a variety of effects, including increased production of growth factors, promotion of capillary circulation, anti-inflammatory effects, and DNA resynthesis.

Chiara Reju stands as the very generic version of Rejuran.and is one of a number of inexpensive formulations that have been manufactured in imitation of Riguran, whose patent has expired. These generic formulations are offered at lower prices than Rejuran because of lower R&D costs.

For more information about Rejuran and Rejuran Hydrophotonic Injections, please click here.

What is Aquatic Light Injection?

The water light injection is a device that injects the drug like a stamp with nine ultrafine needles per shot.
Suction pressure causes the ultrafine needle to penetrate the skin, injecting the drug uniformly at a pre-set depth.

The effect of the preparation and the skin's attempt to heal needle wounds can be expected to increase collagen and regenerate the skin.

See also this article for more information about water light injections.

Effects of Chiara Reju

The effectiveness of Chiara Reju,Basically the same as Rejuran.It is.

  • Improvement of skin quality
  • moisturizer
  • Skin tone improvement
  • Improved skin elasticity
  • Improvement of fine lines and wrinkles
  • Strengthening of the skin barrier function

Ingredients of Chiara Reju

  • Polydeoxynucleotides: skin regeneration
  • Hyaluronic acid: Highly moisturizing, long-lasting
  • Niacinamide: Whitening

Included in the chiarallege areSimilar ingredients to "RejuranIt is.

Hyaluronic acid is found in human skin and cartilage and has a high water retention effect. It decreases with age. Because of its property of being absorbed into the body, it is considered to be relatively safe.

Niacinamide is an ingredient recognized by the Ministry of Health, Labor and Welfare for its "whitening," "wrinkle improvement," and "rough skin improvement" effects.

The following paper reports an improvement in wrinkles and skin texture when polydeoxynucleotides are injected into the lines alone.

Selected right-sided furrows received 4 ml of PN-HPT® (≈polydeoxynucleotide) intradermally during the initial priming phase ("NLF Rx group") and selected left-sided furrows received 4 ml of saline (placebo) ("NLF Lx group"). 3 and 6 weeks later, all patients received 2 ml of subcutaneous cross-linked HA in both NLF areas (4 ml overall).

(omitted) The Antera 3D® device showed significant improvement in wrinkles and skin texture in the NLF Rx compared to baseline at 6 weeks (monotherapy phase) and at 3 and 6 months (PN-HPT® priming + HA phase). HA levels as measured by the quantitative Vectra H2® assessment technique in the right NLF were significantly higher than contralateral at both 3 and 6 months.

PN-HPT® monotherapy was identified as a potentially valuable and effective option for rapid improvement of skin dermal texture and quality in patients with moderate to severe NLF. Acting as a priming agent in the skin, PN-HPT® prolongs the clinical efficacy of cross-linked HA.

Antonino Araco, Francesco Araco, Mauro Raichi. Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross- linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study. Journal of cosmetic dermatology. 2023 Jan;22(1);146-155. doi: 10.1111/jocd.15064.

Features of Smart Skin Clinic's water light injections


chiarralage(Ridgerun Generic)
*Polynucleotide (PDRN) formulation similar to Riguran

1 bottle (2.2cc)
Once24,800 yen → 22,320 yen
3 sets68,400 yen → 58,140 yen
(per time)19,380 yen)
4 sets79,200 yen → 63,360 yen
(per time)15,840 yen)
2 bottles (4.4 cc)
Once34,800 yen → 31,320 yen
3 sets92,400 yen → 78,540 yen
(per time)26,180 yen)
4 sets115,200 yen → 92,160 yen
(per time)23,040 yen)
3 bottles (6.6cc)
Initial Price36,800 yen
Once39,800 yen → 35,820 yen
3 sets104,400 yen →. 88,740 yen
(per time)29,580 yen)
4 sets131,200 yen →. 104,960 yen
(per time)26,240 yen)

Need for anesthesia|High

Prices are all-inclusive, including the cost of anesthesia.
This is because anesthesia is recommended for this procedure, and it is basically standard to perform it after implementing cream anesthesia and local anesthesia.

Chiarlage treatment area

  • Face (forehead, temples, nose, cheeks, fine lines and wrinkles)
  • head
  • low-cut
  • back of the hand

Kiara Rejuvenation is available in a wide range of areas, from the entire face to the neck and décolleté.

Pain during the treatment of Chiara Rejuvenation Hydroxyapatite Injection

  • A stinging pain when the needle is inserted

    Individual differences, use of anesthesia

Kiara Reju water light injections are performed with suction when the needle is inserted, thereby reducing pain.

Because the needles are ultrafine and can be used to inject nine needles at a time, fewer needles are required.

Pain can also be reduced by cooling the affected area and using anesthesia before the procedure. Smart Skin Clinic's fees include the cost of anesthesia.

Duration, longevity, and recommended maintenance frequency of the effects of Kiaralleju

The effect will be apparent at the right time.

  • Moisturizing and toning effects = immediately after
  • Skin regeneration effect = after approx. 2-4 weeks

Recommended number of treatments

  • About 3-4 times, 2-4 weeks apart (= 1 course)

[Duration of effect].

  • More than 1 year
    *In case of 1 course of treatment

Recommended maintenance frequency

  • 1 course every 6 months to 1 year

Initially, the hyaluronic acid will moisturize and tone the skin, and after 2 to 4 weeks, the skin-regenerating effects of the polydeoxynucleotides will become apparent.

As with Rejelan, a single treatment is effective, but the effects are more easily felt by repeating the treatment.

Recommended injection volume for Kiarareju

Pattern 1] The forehead and the area from the nose down can be lighter ⇒ 3cc

Pattern 2] The area from the nose down can be lightened a little, but from the nose up, it should be done firmly ⇒ 4cc

Pattern (3)] The entire face, including the nose and below the nose, should be done thoroughly ⇒ 6cc

See also this illustration for more details.

If you are not sure which dose is right for your condition, please contact us during the counseling session.

Downtime and risks of Chiara Rejuvenation Hydroxyapatite Injection

The biggest concern with Chiara Rejuvenation Hydroxyapatite injections is the effect on postoperative life.

Downtime of Chiara Rejuvenation Hydroxyapatite Injection


  • About 2 to 3 days


  • Redness and bumpy bumps at the site of needle puncture: disappear within 24 hours
  • Tingling pain: several days
  • Internal bleeding: Gradual disappearance over 10-14 days

Pain and swelling can be relieved by cooling. Wrap a coolant or other coolant in a clean cloth and apply it intermittently to the affected area.

For more information about the downtime of hydroxyapatite injections, please also see here.

How to spend time after Chiara Rejuvenation Hydroxyapatite Injection

After the surgery, please pay attention to the following points.

  • Skin care: Possible immediately after the treatment
  • Shower: possible on the same day
  • Makeup: possible after about 24 hours

There is no major impact on daily life after Chiara Rejuvenation Hydroxyapatite Injections. If you work at a desk, you can do so as usual. If internal bleeding occurs, it can be covered with concealer.

However, inside the skin, the skin is trying to repair wounds that cannot be seen. Please avoid prolonged bathing, strenuous exercise, massages, and other activities that increase circulation, which can impede recovery. This may increase downtime symptoms.

Risks of Chiara Rejuvenation Hydroxyapatite Injection

In addition to downtime symptoms, Chiara Rejuvenation x Hydroxyapatite Injection treatment has the following side effects.

  • pigmentation
  • infection
  • allergy

After surgery, do not touch the affected area more than necessary. It may cause pigmentation or infection. In addition, skin in the process of regenerating can cause various skin problems as well as pigmentation, so be sure to keep your skin moisturized and protected from UV rays.

Swelling, pain, and redness are similar to downtime symptoms, but usually subside over time. Increased symptoms are an important sign of allergy. Consult the clinic as soon as you notice it.

Note that Kiaralleju, like Rejelan, is derived from salmon, so it cannot be used by those who are allergic to fish.

Chiaralleju treatment method

The procedure takes about 30-40 minutes excluding counseling and about 60 minutes including anesthesia.
The flow of the treatment is as follows



You can easily make reservations with your mobile phone.

Reception (desk)

This is a "smart" and easy receptionist service that can be completed immediately by the clinic's IT system by simply providing your name.

Counseling and medical examination

Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.


Cream anesthesia is applied, local anesthesia is administered, and the injection is carried out while the patient is asked.

After-sales service

We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.

Returning home

To avoid failure with Chiara Rejuvenation Hydroxyapatite Injections.

  • Select a reliable clinic based on case results and reviews.
  • Ensure that the fee is set at a rate that you can continue to pay.
  • Share your concerns and ideals with the doctor in a counseling session, confirm indications, treatment details, and downtime, and only then accept the treatment after you are satisfied with it.
  • Observe postoperative precautions
  • Receive treatment at recommended frequency and maintenance frequency

Even for the same procedure, the skill level and fee structure vary from clinic to clinic.

Be sure to check the finished product image and the concept of downtime. In Japan in particular, many people want a procedure that has as little impact on their daily lives as possible, and in some cases, clinics overseas are not as concerned about downtime as Japanese clinics are. The depth of the needles and suction pressure can be adjusted, so consult with the clinic carefully.


Treatment Time30~40 minutes (not including counseling)
Recommended number and frequency of treatmentsWe recommend 3 to 4 sessions with an approximate interval of 2 to 4 weeks.
Down timeAbout 2 to 3 days
Treatment on the day of counselingPossible
MakePossible after about 24 hours
Skin carePossible immediately after the treatment
ShowerPossible from the same day
PainThere is a stinging pain when the needle is inserted.
*There are individual differences.

Go to Smart Skin Clinic for Chiara Reju Hydrophoton injections.

Smart Skin Clinic's Kiara Rejuvenation Hydroxyapatite Injection has 9 ultra-fine needles, depth can be adjusted from 0.6 to 1.2 mm under the skin, and the injection volume can be controlled.

Fees are clearly stated. We offer a one-time fee that is easy to try, and a three- or four-time set fee that is easy to continue, in three different units of 2.2㏄/4.4㏄/6.6㏄ per unit, depending on the coverage area and your convenience.

If you have any questions, please feel free to contact us for a free consultation. Our doctors will propose the most appropriate treatment.


Antonino Araco, Francesco Araco, Mauro Raichi. Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross- linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study. Journal of cosmetic dermatology. 2023 Jan;22(1);146-155. doi: 10.1111/jocd.15064.