A doctor explains the downtime of Rejuran! From duration and symptoms to countermeasures

I wonder how long the downtime period would be for Rejuran."
Are the downtime symptoms of Rejuran severe?"
Will my work and daily life be affected during the downtime?"

Do you have any of these concerns about Rejuran?

Hello. I am a doctor at Smart Skin Clinic.

Rejuran is an injection treatment for various skin problems. In this article, the cosmetic dermatology clinic will discuss the downtime of Rejuran, its duration and symptoms, how to spend the downtime, and how to avoid suffering from downtime.

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Effects of Rejuran

Rejuran is an injectable with polynucleotides (PN) derived from salmon as its active ingredient. Polynucleotides are portions of DNA.

Subcutaneous injection of the preparation is expected to stimulate fibroblasts in the dermis layer to stimulate the production of collagen and elastin to restore firmness and elasticity, increase vascular endothelial growth factor for wound healing, and decrease inflammatory cytokines for anti-inflammatory effects.

Recommended for those suffering from all signs of aging, including lack of firmness, dullness, fine lines, wrinkles, craters, and dark circles under the eyes. It can be used not only on the face, but also on the neck, décolleté, and back of hands.

Downtime duration and symptoms of Rejuran

The downtime period for Rejuran is a few days. Symptoms include mild pain, swelling, and internal bleeding.

These symptoms are normal reactions after injection treatment. The appearance of downtime symptoms varies from person to person and depends on the treatment method and site of treatment.

  • Pain
  • Swelling (small bulges similar to insect bites, sometimes with redness)
  • internal hemorrhage

The fact that Rejuran rarely causes serious side effects is described in many papers, including the following study in which "20 Caucasian women aged 40-65 years were injected with a polynucleotide-containing preparation (≒Rejuran) into their laugh lines.

Following a split-face design, the selected right NLF received 4 ml of PN-HPT® intradermally during the initial priming phase ("NLF Rx group") and the selected left NLF received 4 ml of saline (placebo) ("NLF Lx group"). 3 weeks and 6 weeks later, all patients received 2 ml of subcutaneous cross-linked HA in both NLF sites (4 ml overall). 6 weeks, 3 months and 6 months later, objective evaluations based on Antera 3D® and Vectra H2® qualitative and quantitative skin imaging techniques were performed. (omitted) All treated women completed the 6-month follow-up without reporting any clinically minor side effects.

Antonino Araco, Francesco Araco, Mauro Raichi. Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross- clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross- linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study.

Progress of downtime for Rejuran

The following is a progression of downtime for Rejuran.

immediately after surgery

A raised area may appear at the injection site, but it will settle down within a few hours to a day. If internal bleeding occurs, it will be dark purple at first.

Facial cleansing and showering are allowed on the same day.

day after next

Pain and swelling will gradually subside and become barely noticeable. Makeup can be applied after 24 hours.

3 days later

Downtime is almost over. Internal bleeding gradually fades to yellow.

1 to 2 weeks later

Internal bleeding will have gradually disappeared by this time.

Risks of Rejuran

Rejuran is a formulation with relatively few side effects and risks, but there is a risk of allergy and infection.

Rejuran uses ingredients extracted from salmon DNA. If you are allergic to fish, you may not be able to undergo the procedure because of the possibility of allergic reactions.

Swelling and pain should subside within a few days, but if they gradually intensify, you may have an infection and should consult a clinic.

There is no difference in downtime between different types of Rejuran.

There are four types of Rejuran formulations for different purposes. Rejuran (Healer)" for powerful skin texture improvement, "Rejuran i" for the eye area, "Rejuran s" for pinpoint use on scars, and "Rejuran HB" with anesthesia to reduce pain.

There is no difference in the duration and symptoms of downtime for any of these products. However, Rejuran (Healer) is more painful during injection than the other three preparations, and internal bleeding is more likely to occur if the patient strains.

Note that some clinics may combine Rejelan with other formulations and treat it as an original treatment. In some cases, downtime and precautions may increase with the combined formulation, so you will need to check separately.

How to spend downtime with Rejuran

We will give you advice on how to spend your time to reduce downtime symptoms of Rejuran.

not touch the affected area

Be careful not to touch the affected area after surgery more than necessary.

Because Rejuran is an injection treatment, it points to a needle. If bacteria enter through the needle hole, it can cause infection and slow wound healing.

Swelling and pain are relieved by cooling

The postoperative pain of Rejuran is not so strong as to be unbearable. However, the pain felt varies from person to person.

If swelling and pain are painful, intermittent cold can reduce pain. Do not apply ice directly or for long periods of time, as this may cause frostbite.

Prevent skin problems by moisturizing and thoroughly protecting against ultraviolet rays.

Although a Rejuran wound is only a needle hole in appearance, the needle passes under the skin, so the wound needs to be repaired, and the barrier function that protected the skin is reduced.

When the barrier function is reduced, moisture inside the skin evaporates more easily, making it more susceptible to external damage such as ultraviolet rays.

Moisturizing and UV protection are daily habits to keep in mind, but during the downtime period, you should pay even more attention to them. Moisturize with heavier cream than usual, wear a parasol or a mask that can block ultraviolet rays. Use of harsh skin care and makeup products should also be avoided during this period.

Observe life precautions

During the downtime of Rejuran, the skin is in a delicate state.

There are no major restrictions on daily activities; however, avoid strenuous exercise, prolonged bathing, and heavy drinking that may stimulate blood flow.

Make sure to consume a nutritionally balanced diet and get enough sleep to promote skin regeneration.

Internal bleeding can be covered with makeup.

In most cases, internal bleeding can be concealed with makeup such as foundation or concealer.

You may be surprised by the dark purple color at first, but rest assured that it will gradually fade and disappear over a period of 10 to 14 days.

Choosing a clinic to avoid downtime problems with Rejuran.

To avoid suffering from Rejuran downtime, choose a clinic with a proven track record and aftercare support.

In order to achieve a satisfactory result, check the case results, and if you have any questions, ask them repeatedly during the consultation, and only proceed with the procedure after you are satisfied with the results.

In case there are any postoperative side effects or problems, we will also check if they can be handled immediately.

Smart Skin Clinic provides the following services, from a single point of care to aftercare.

Maintenance after downtime of Rejuran

Rejuran does not have an immediate effect, but you will notice improvements in skin texture and other effects in about 2 to 4 weeks due to collagen production.

In order to maintain the effect, we recommend a course of "3-4 times every 2-3 weeks" in accordance with the turnover, followed by regular maintenance about every 6 months to 1 year.

Frequently asked questions about downtime for Rejuran

The following are answers to frequently asked questions about downtime for Rejuran.

Q.How long will the postoperative swelling last?

Swelling after the Rejelan procedure is barely noticeable the next day and subsides within a few days.

Q.Is there anything I should be aware of during the downtime?

During the downtime of Rejuran, avoid touching the wound as much as possible and do not overheat the body. Work on moisturizing and UV protection.

Kiara Reju, a polynucleotide formulation similar to Rejuran

Chiara Rege Product Images

Rejuran is a formulation whose main ingredient is a polynucleotide (PDRN).

This polynucleotide is sometimes called "salmon injection" because it is derived from salmon.

Rejuran was patented as a formulation using this "polynucleotide," but this patent has recently expired, and several inexpensive formulations using polynucleotides are now available.

One of these will be "Kiara Reju" injections.

Like Rejuran, it is a polynucleotide-based formulation and is less expensive than Rejuran.

At Smart Skin Clinic, the following prices are available for Chiara Rejuvenation injections with water light injections.

1 bottle (2.2cc)
Once24,800 yen → 22,320 yen
3 sets68,400 yen → 58,140 yen
(per time)19,380 yen)
4 sets79,200 yen → 63,360 yen
(per time)15,840 yen)
2 bottles (4.4 cc)
Once34,800 yen → 31,320 yen
3 sets92,400 yen → 78,540 yen
(per time)26,180 yen)
4 sets115,200 yen → 92,160 yen
(per time)23,040 yen)
3 bottles (6.6cc)
Initial Price36,800 yen
Once39,800 yen → 35,820 yen
3 sets104,400 yen →. 88,740 yen
(per time)29,580 yen)
4 sets131,200 yen →. 104,960 yen
(per time)26,240 yen)

If you are interested in Chiara Lege, please also see the following articles

For Rejuran, go to Smart Skin Clinic.

Have your concerns and questions about the downtime of Rejuran been answered?

Rejelan is a treatment with light downtime. However, symptoms may vary from person to person, so if you have any concerns, please feel free to discuss them with us at a free consultation.

For more information about Smart Skin Clinic's Rejuran, please see below.

In addition, we are committed to the following injectable treatments, including Rejelan.

Reference

Antonino Araco, Francesco Araco, Mauro Raichi. Clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross- clinical efficacy and safety of polynucleotides highly purified technology (PN-HPT®) and cross- linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study.

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