［Tokyo] Exosome infusion [umbilical cord-derived] (inexpensive)
"What is an exosome infusion?"
"I am comparing clinics for exosome infusion and am concerned about the price, etc."
"I want to receive umbilical cord derived exosomes."
Hello, I am a doctor at Smart Skin Clinic, a cosmetic dermatology clinic.
Do you have any of these questions or concerns?
In this article,Ministry of Health, Labour and WelfareThe following is an easy-to-understand explanation from a professional standpoint by a cosmetic dermatology clinic that is a member of the "Aesthetic Dermatology Clinic".
(* Type II and Type III Regenerative Medicine Provisioning Plans Accreditation Number: NA8230001)
*If you would like to know the rates, you can jump to the appropriate section from the table of contents below.
What is exosome infusion therapy?
Summary
By administering a component called exosomes into the blood vessels,Anti-aging effect on the entire bodyThis is an intravenous drip treatment that can be expected to
What is an exosome?
Exosomes are substances originally found in the body. In medical terms, they are small cellular vesicles encased in a lipid bilayer membrane that are actively secreted by various cells and play an important role in intercellular communication.
Through this role of intercellular communication, exosomes exert diverse effects, including anti-apoptotic, anti-inflammatory, neurogenic, and angiogenic effects. As a result of exerting these effects, they provide so-called anti-aging effects.
Exosomes are granule-like substances 50-150 nm (nanometers: one billionth of a meter) in diameter secreted by cells.
One important function of exosomes that has been highlighted is that they are used to transfer information between cells. Exosomes are thought to act as communication tools between cells.
Tokyo Metropolitan Institute of Gerontology and Geriatric Medicine
Types of exosomes (origin)
Exosomes can be said to come in three types because there are three main sites (origins) from which they are harvested.
These will be the following three
- Umbilical cord-derived
- Fat-derived
- Bone marrow and dental pulp derived
Effect
The effects that can be expected from exosome infusion are as diverse as the images below. This is due to the fact that exosomes are involved in intercellular communication and act in a way that activates cells, as well as acting throughout the body.
We will pick up a few of the diverse effects and explain them in detail.
Anti-aging(Rejuvenation), effects on the whole body
Anti-aging is a comprehensive concept, not just a part of the body, or rejuvenation at the cellular level, which is invisible to the eye.
Exosome infusion acts on cells throughout the body and is expected to achieve anti-aging results.
Relieve fatigue and maintain health
Exosomes acting throughout the body can be expected to help recover from fatigue at the cellular level. Cell repair and anti-inflammatory effects of exosomes are thought to be involved.
Effects on skin
As shown in the Rohto study below, exosomes act on fibroblasts, which are cells deep in the skin, to synthesize collagen and elastin, which affect skin elasticity and luster. This is expected to have a skin beautifying effect.
We found that it inhibits fibroblast senescence via exosomes and promotes the synthesis of dermal components such as collagen and elastin.
Rohto Pharmaceuticals] Discovered an ingredient (glycogen/tetrapeptide-5) that inhibits fibroblast aging via exosomes, which is attracting attention in regenerative medicine research.
Effects on the brain (improved insomnia, improved concentration, improved cognitive function)
The cell repair and anti-inflammatory effects of exosomes are thought to have a positive effect on the brain as well, and can be expected to improve insomnia and improve concentration by healing the brain.
Exosomes are thought to have a potential effect on Alzheimer's disease-causing agents such as amyloid-β and tau proteins, and are expected to have a positive effect on cognitive function.
Reduced downtime
Exosomes are transported throughout the body via the bloodstream and move freely between tissues, exerting anti-inflammatory, antioxidant, and cell repair effects through angiogenesis and other actions.
This mechanism is expected to accelerate wound healing and reduce downtime.
Effect on hair
Just as it acts on the skin, etc., hair is made of "cells," so exosomes act on hair and may be expected to improve elasticity, firmness, and even gray hair.
Effects on immunity and allergic diseases
It has been suggested that exosomes may contribute to improved immunity, as described in the following medical article.
These results indicate that circulating exosomes containing spike proteins play an important role in effective immunization following mRNA-based vaccination. This is further evidenced by the induction of humoral and cellular immune responses in mice immunized with exosomes carrying spike proteins.
Sandhya Bansal, et al. Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer-BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines. J Immunol (2021) 207 (10): 2405- 2410.
In this video, Takafumi Horie (Holliemon) and Dr. Yamakawa explain about exosomes.
Evidence/Data
Various studies are underway on the evidence for exosome infusion, as cited in the effectiveness section.
Clinical studies are still being conducted to treat various diseases such as stroke, liver cirrhosis, cancer, lymphedema, joint diseases, and dementia.
Those who cannot be treated
Basically, those who fall into the following categories are not eligible to receive Exosome infusion.
Also, please be assured that you will be examined by a physician prior to the procedure.
- Want to donate blood or have a blood transfusion in the future (you will not be able to donate blood or have a blood transfusion after receiving the exosome infusion)
- I've had allergies to exosome-related procedures in the past.
- Currently suffering from an infectious disease or immunosuppressed state
- Pregnancy and lactation
- Have a history of cancer or currently have cancer (due to the possible risk of exosomes promoting cancer growth)
- Have a blood disorder, such as a coagulation disorder, or are taking anticoagulants
- Have an autoimmune disease or a disease related to the immune system
- (Caution is required.) Has not had a recent physical examination or is uncertain about his/her health status.
Risks and Side Effects
Some common risks and side effects that can occur with exosome infusion include the following
- Pain at puncture site, internal bleeding, neuropathy
- Other physical symptoms such as headache, nausea, etc.
- Rarely, an anaphylactic reaction (acute allergic reaction) may occur
Also unique to exosomes is the section on their impact on cancer and the section on blood donation.
Danger of promoting cancer
It is said to have the potential to promote cancer cell growth in the presence of cancer cells.
Faezeh Vakhshiteh, et al. Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy.
Int J Nanomedicine. 2019 Apr 23:14:2847-2859.
On the other hand, there have been reports of contrary research, such as suppressing the growth of cancer cells.
For safety reasons, we do not treat patients who have been diagnosed with cancer or who have not had a physical examination in many years and whose current health status is unknown.
I won't be able to donate blood.
After the infusion, blood donation and transfusion will not be allowed.
Recommended for the following problems
- I have insomnia.
- Want to relieve fatigue and improve malaise
- I want to improve my immune system.
- I want to restore the elasticity and luster of my skin.
- I want to restore the elasticity of my hair.
- I want to do anti-aging.
- I want to improve my physical condition.
- I want to regain my youthfulness.
- I want to improve my allergies.
- I want to improve my joint and limb pain.
Demerit
One of the disadvantages of the Exosome infusion is that it makes it impossible to donate blood in the future.
There are no other major disadvantages, but the following article explains them in detail for those who are interested.
Exosome infusion at Smart Skin ClinicFeatures of
Use of umbilical cord-derived exosomes
SmartSkin Clinic uses exosomes derived from the umbilical cord, which are one of the three major types of exosomes: (1) umbilical cord-derived, (2) fat-derived, and (3) pulp/marrow-derived.
When compared to other exosomes, umbilical cord-derived exosomes contain 14 times more effective components, as shown in the figure below.
We will also introduce two of these "active ingredients," including specific data.
(1) Rich in active ingredients for skin
The first is data on the active ingredients for "skin".
Exosomes have various anti-aging effects, one of which is the effect on "skin. As shown in the figure below, umbilical cord-derived exosomes contain more active ingredients for skin than other exosomes.
(2) Rich in rejuvenating protein "GDF-11
The second will be data on ingredients involved in "rejuvenation.
There is a component called GDF-11, which is involved in rejuvenation, and is abundant in umbilical cord-derived exosomes, as shown by the following data.
In accordance with MISEV2018, Minimal Information for Studies of Extracellular Vesicles (MISEV) 2018
In exosomes, extraction methods, exosome size, storage methods and shapes vary.
For this reason, the International Society for the Study of the Endoplasmic Reticulum (ISEV) has established guidelines for the standardization of exosome protocols.
The guidelines proposed by ISEV will be the Minimal Information for Studies of Extracellular Vesicles (MISEV) 2018 Edition.
We perform extraction and purification in accordance with misev2018 at our cell culture and processing facility, which is then used at our hospital.The Company has been working on the following
Safety Initiatives｜Compliance with the Guidance of the Japanese Society for Regenerative Medicine
Our exosome infusion therapy is performed in accordance with "Guidance on the Clinical Application of Extracellular Vesicles, etc. (1st Edition)" released on April 30, 2024, by the Japanese Society for Regenerative Medicine.
This guidance is an important guide to ensure the safety and efficacy of exosome therapy, and our guidance-based rigorous quality control and safety efforts.
Specific Efforts to Ensure Safety at the Hospital
- Conduct risk profiling
- Potential risks associated with treatment are identified and appropriate measures are taken.
- Rigorous preparation process and quality control
- Our manufacturing process and quality checks are based on the latest scientific findings.
- Implementation of appropriate effectiveness verification
- We continually evaluate the effectiveness of treatments and provide the best possible treatment for our clients.
Your safety is our first priority, and we promise to provide treatment based on the latest scientific findings.
What is Exosome Nasal Drops?
Exosomes can also be administered by "nasal drops". Like nasal drops for hay fever, it can be administered at home.
The following article explains in detail for those interested.
Flow of treatment
You can easily make reservations with your mobile phone.
This is a "smart" and easy receptionist service that requires only that you give us your name.
Please feel free to discuss any concerns you may have during the counseling session. Please be assured that there is no pushy sales.
Please be assured that the IV infusion is administered in the same way as a regular IV infusion.
We will explain in detail about the care of the treated area and precautions for daily life. We also suggest appropriate home care from the viewpoint of prevention and maintenance, such as oral medicines and skin care cosmetics that can be expected to improve your problems.
Charge
intravenous drip
250mg
| Initial Price | |
| Once | 23,000 yen |
| 3 times | 65,500 yen (21,833 yen per session) |
| 5 times | 99,800 yen (19,960 yen per session) |
| 10 times | 179,000 yen (per time)17,900 yen) |
500mg
| Initial Price | |
| Once | 36,800 yen |
| 3 times | 99,800 yen (33,266 yen per session) |
| 5 times | 159,800 yen (31,960 yen per session) |
| 10 times | 289,800 yen (per time)28,980 yen) |
1,000 mg
| Initial Price | |
| Once | 73,600 yen |
| 3 times | 199,600 yen (66,533 yen per session) |
| 5 times | 319,600 yen (63,920 yen per session) |
| 10 times | 579,600 yen (per time)57,960 yen) |
2,000 mg
| Initial Price | |
| Once | 119,800 yen |
| 3 times | 341,400 yen (113,800 yen per session) |
| 5 times | 544,000 yen (108,800 yen per session) |
| 10 times | 978,000 yen (per time)97800 yen) |
nose drops
| 5cc per bottle [for one week]. | |
|---|---|
| Initial Price | 29,440 yen |
| one (object) | |
| Set of 2 bottles (for 2 weeks) | (35,800 yen per bottle) |
| Set of 4 bottles (1 month's supply) | (32,800 yen per bottle) |
| Set of 12 (3-month supply) | (28,800 yen per bottle) |
Insurance Coverage
Exosome infusion is not covered by public medical insurance.
Since it is free medical treatment, it is handled in the same way as for ordinary cosmetic procedures.
If you would like to know more details, please see the following article for a detailed explanation.
FAQ
- Is it effective even if it is done once?
Dr. Smaski.Even one time is effective. However, the Exosome infusion is a procedure that must be repeated to realize significant results. Therefore, we recommend 8 to 12 sessions of infusions, each session lasting 1 to 2 weeks.
- Will it affect genes, etc.?
- Dr. Smaski.
No data from previous studies have shown that genetic information is altered.
- Can exosomes cause cancer?
- Dr. Smaski.
Basically, no. Exosomes themselves are not thought to induce cancer. On the other hand, if cancer is present in the body, it may activate cancer.
- Are allergic reactions safe?
- Dr. Smaski.
If allergies are confirmed in advance, the risks are not significantly different from those of a typical infusion. In the event of an allergic reaction, please be assured that a physician will be available to help you.
More Information
| Treatment Time | 15~30 min. |
| Recommended number and frequency of treatments | About 5 times, every month or so. |
| Down time | almost never |
| Treatment on the day of counseling | Possible |
| Pain | Tingling needle pain during normal injections and infusions |
References/Literature
・Tokyo Metropolitan Institute of Gerontology and Geriatric Medicine
Smart Skin Clinic
Smart Skin Clinic
The concept of the clinic is to "make cosmetic medicine more accessible and smart.
The clinic's concept is to make cosmetic medicine more accessible and smart.
The clinic has eliminated gaudy interior design to reduce interior costs, and instead of introducing equipment in the dark, it carefully selects the equipment it needs and reduces the cost of the equipment.
We aim to "make cosmetic medicine more accessible to as many people as possible.
Address: 8F EX Kanda Nishiki-cho Building, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic Dermatology (aesthetic dermatology, medical hair removal, medical slimming)
Address: 8F EX Kanda Nishiki-cho Building, 3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo
Specialty: Cosmetic Dermatology (aesthetic dermatology, medical hair removal, medical slimming)
About the physician supervision of this site
About the physician supervision of this site
This site is operated under the supervision of the Smart Skin Clinic supervising physicians.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.
This page is produced under the supervision of our supervising physician, who also operates the website as a medical institution in accordance with the Medical Advertising Guidelines, which were revised and enforced in June 2018.