PLURYAL SILK [Injection formulation exclusively for the eye area

*Number of cases | During the period from September 1, 2023 to March 31, 2024

Hello, I’m a doctor at Smart Skin Clinic, a cosmetic dermatology practice.

Do you have questions like these?

In this article, we’ll provide an easy-to-understand explanation from a professional cosmetic dermatology perspective about “Puralia Silk,” one of the four products in the Puralia Densifia series.

*If you’d like to know the pricing, you can find it right away in the table of contents below.

Supervisor Information

Group Chief Director, Smart Skin Clinic Group

IshiiIshii KotaKota

Career

Graduated from Juntendo University School of Medicine

Worked at Tokyo Women's Medical University Hospital and affiliated facilities

Worked at a major aesthetic clinic in Tokyo

Affiliations / Qualifications

Board-certified specialist, Japan Surgical Society

Board-certified specialist, Japanese Society of Anti-Aging Medicine

What is Pluryal Silk?

Pural Silk is a formulation developed specifically for use around the eyes. It has obtained CE approval for use around the eyes and is an injectable formulation that is rapidly gaining popularity, particularly in Europe.

It has the following three features:

1. CE approved exclusively for use around the eyes: Its safety and effectiveness for the delicate area around the eyes have been recognized.
2. A high-purity polynucleotide (PN) formulation: A special purification technology simultaneously maximizes its effectiveness while minimizing the risk of allergy.
3. A formulation designed to suit delicate areas: Specially designed to have the right viscosity and penetration for thin, delicate skin areas such as around the eyes and mouth.

Its position within the Pluryal series

Prurial Silk is the only product in the Prurial series that is specifically designed for the eye area.

While the series also includes products like Plurial Densify for the entire face and Plurial Hair Density for hair growth, Plurial Silk holds an important place within the series as a formulation optimized for the specific area around the eyes.

Main ingredient: About polynucleotides (PN)

The main ingredient of Pluryal Silk, polynucleotides (PN), is a highly purified PN derived from salmon. This PN offers a variety of benefits.

1. Increased skin hydration: PN has high water-retention properties and improves the skin's ability to hold moisture.
2. antioxidant action: PN has a powerful antioxidant action and helps prevent skin damage caused by free radicals. This may help slow down the skin's aging process.
3. anti-inflammatory action: PN has an anti-inflammatory action and helps calm skin inflammation.
4. Promotes fibroblast proliferation: PN promotes the proliferation of fibroblasts. Fibroblasts are important cells that produce collagen and elastin, and their proliferation leads to improved skin elasticity.
5. DNA repair and regeneration: PN promotes DNA repair and regeneration. This helps skin cells recover from damage caused by factors such as UV rays.
6. Promotion of angiogenesis: PN promotes the secretion of vascular endothelial growth factor (VEGF) and encourages angiogenesis. This improves blood flow in the skin and enhances the supply of nutrients.

The areas Pluryal Silk can treat

Pluryal Silk (PLURYAL SILK) can be applied mainly to the following areas:

• Around the eyes
• Around the mouth
• Other delicate areas (such as scars)

Effective for concerns such as these

Pluryal Silk is especially effective for those with the following concerns:

• Those concerned about wrinkles or sagging around the eyes
• Those concerned about dark circles under the eyes
• Those concerned about fine wrinkles around the eyes and mouth
• Those with skin problems due to chronic inflammation (such as hyperpigmentation from atopic dermatitis or redness from acne scars)
• Those who feel their skin has lost firmness and elasticity

Until Pluryal Silk came along, concerns around the eyes (dark circles, fine lines) were among the most difficult to address. It was against this backdrop that Pluryal Silk was developed.

Expected benefits

With Pluryal Silk, you may expect benefits such as the following:

1. Improvement of wrinkles and sagging: Through PN's cell-regenerating effect, the production of collagen and elastin is promoted, which helps improve wrinkles and sagging.
2. Improvement of skin quality: Through PN's moisturizing and cell-regenerating effects, skin texture is refined and overall skin quality improves.
3. Improvement of dark circles: Thanks to its angiogenesis-promoting and anti-inflammatory effects, it may help improve dark circles and dullness under the eyes.
4. Reduction of redness: Its anti-inflammatory action helps reduce chronic redness and inflammation.
5. Improvement of skin firmness and elasticity: An increase in collagen and elastin improves the skin's firmness and elasticity.
6. Long-term skin rejuvenation: With continued use, the skin's regeneration cycle is activated, and a long-term rejuvenating effect can be expected.

*These effects vary depending on individual differences and skin condition.

Rather than delivering an immediate effect, Pluryal Silk (PLURYAL SILK) is distinctive for gradually enhancing the skin's natural functions. This allows for natural rejuvenation, and it may improve skin quality without giving the impression that any treatment has been done.

The mechanism of action of Pluryal Silk

Pluryal Silk delivers its effects through the following mechanisms:

1. Tissue regeneration: PN activates fibroblasts and promotes the production of collagen and elastin.
2. Angiogenesis: It promotes the secretion of VEGF and encourages the formation of microvessels. This improves the skin's nutritional state.
3. anti-inflammatory action: It suppresses the production of inflammatory cytokines and reduces chronic inflammation.
4. Scar repair: It promotes the rebuilding of the extracellular matrix and contributes to the improvement of scars.

Features of Smart Skin Clinic’s Plural | Our ”Commitment“ to Injectable Formulations“

Following our director's philosophy, we perform injections with the following "attention to detail."

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Plural Silk: Downtime and Post-Treatment Care

Plural Silk is a formulation developed specifically for the eye area; it is injected in small amounts using ultra-fine needles into the thin, delicate skin around the eyes. Although bruising may occur in rare cases, it is said to gradually fade over the course of about 1 to 2 weeks. At our clinic, we take measures to minimize the risk of bruising, such as using ultra-fine needles.

Guidelines for Aftercare

Item	Guideline
Swelling, Redness, and Pain	Even if they occur, they usually resolve within 24 hours.
Bruising at the injection site	Dark circles may appear around the eyes, and when they do, they usually fade gradually over the course of 1 to 2 weeks.
Makeup and face washing	Makeup can be applied the same day (bruises can be covered with concealer)
Bathing, Exercise, and Alcohol Consumption	Avoid strenuous exercise and alcohol consumption on the day of the procedure, and limit your exposure to high-temperature environments, such as hot stone baths and saunas, for about a week.
Guidelines for Continuation	For the initial series, 3 to 4 sessions are recommended at intervals of 2 to 3 weeks; thereafter, your doctor will make recommendations based on the results.

The extent of bruising varies from person to person. Please allow plenty of time before any important events. If you have any pre-existing medical conditions, are taking medication, or are pregnant or breastfeeding, be sure to consult your doctor before undergoing treatment.

Pricing

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Treatment Method

The Pluryal Silk procedure is carried out as follows:

1. Counseling: We listen carefully to your concerns and wishes and assess your skin condition in detail. We then propose the treatment plan best suited to you.
2. Preparation before treatment: We thoroughly clean and disinfect the treatment area. We apply a local anesthetic cream if needed.
3. Injection: Using a special fine needle or cannula, we inject a small amount into the necessary areas, such as around the eyes and mouth.
4. Explanation of aftercare: We explain the precautions and appropriate skincare in detail and confirm your next treatment appointment.

The procedure usually takes about 20 to 30 minutes. Including counseling and preparation time before and after the procedure, we ask that you plan to be at the clinic for about an hour.

Recommended number/frequency of treatments

The standard treatment plan for Pluryal Silk is as follows:

• Initial treatment: 3 to 4 treatments at intervals of 2 to 3 weeks
• Maintenance: 1 treatment every 6 to 12 months, depending on results

That said, because results from cosmetic dermatology treatments vary from person to person, this is only a general guide.

Side effects and risks

Plural Silk is extremely low-risk in terms of allergies. Common side effects include the following:

• Redness, swelling (puffiness), and pain at the injection site
• Bruising

In most cases, these reactions return to normal within 24 hours.However, if bruising occurs, it will gradually fade over the course of a week or two.

At our clinic, we make every effort to minimize the risk of bruising, such as by using ultra-fine needles.

Aftercare

After the procedure, please keep the following points in mind:

• Avoid strenuous exercise and alcohol on the day of treatment
• Avoid high-temperature environments such as stone-bath spas and saunas for about a week
• Do not touch the treated area unnecessarily
• Follow your doctor's instructions for skincare

By following these precautions, you can achieve safer and more effective results.

Frequently Asked Questions (FAQ)

Q1: When can I start to see results?

A: The point at which results are felt varies from person to person, but the general timeline is as follows:

• Immediately after treatment: Some people feel a mild sensation of firmness.
• After 1 week: Many people begin to notice a mild improvement, with the skin starting to look firmer and more radiant.
• After 2 to 4 weeks: Collagen production becomes more active, and the full effect begins to appear.
• After 2 to 3 months: This is when the greatest effect appears.

Rather than acting immediately, Pluryal Silk has the distinctive quality of gradually improving the skin.

Q2: From what age can I receive this treatment?

A: There is no specific age limit, but generally people from their late thirties to their sixties are the most common recipients. Those who wish to start care earlier, as well as younger people, can also receive it. However, those under 18 require parental consent.

Q3: Is it painful?

A: Because an extra-fine needle is used, the pain is relatively mild. Many patients describe it as no more than a slight stinging or pressure. If you wish, a local anesthetic cream can be used, so please rest assured.

Q4: How long do the effects last?

A: This varies from person to person, but the effects usually last about 6 months to 1 year. With regular maintenance (about one treatment every 3 to 6 months), you can maintain the effect over a longer period.

Q5: Can I receive the treatment while pregnant or breastfeeding?

A: For safety reasons, we do not recommend this procedure for those who are pregnant or breastfeeding. We recommend receiving the procedure after pregnancy and breastfeeding are complete.

Q6: Can it be combined with other cosmetic treatments?

A: Yes, it can be combined with many cosmetic treatments. In particular, it is considered to pair well with botulinum toxin and laser treatments. However, when combining treatments, an appropriate interval between them is necessary, so we recommend consulting your doctor beforehand.

Q7: What should I be careful about in aftercare?

A: After the procedure, please keep the following points in mind:

• Avoid strenuous exercise and alcohol on the day of treatment
• Avoid high-temperature environments such as stone-bath spas and saunas for about a week
• Do not touch the treated area unnecessarily
• Please follow your doctor's instructions for skincare

Q8: How much does it cost?

A: Costs vary from clinic to clinic. In Tokyo, the going rate is roughly 50,000 to 100,000 yen per treatment. (as of June 2025)

Pluryal Silk vs. other eye area treatments

Let's compare Pluryal Silk with other common eye area treatments.

1. Comparison with botulinum toxin

Botox

• Main effects: Improvement of expression lines and reduction of crow's feet at the corners of the eyes
• Mechanism of action: Inhibits muscle movement
• Duration: 3 to 6 months
• Characteristics: Acts quickly, but the natural look of expressions may be compromised

Pluryal Silk

• Main effects: Wrinkle improvement, better skin quality, and improvement of dark circles
• Mechanism of action: Promotes cell regeneration and collagen production
• Duration: 6 months to 1 year
• Characteristics: Allows long-term improvement of skin quality while maintaining natural expressions

Unlike botulinum toxin, Pluryal Silk (PLURYAL SILK) does not inhibit muscle movement, so it provides a rejuvenating effect while preserving more natural expressions. You can also expect a fundamental improvement in skin quality.

2. Comparison with hyaluronic acid injection

Hyaluronic acid injection

• Main effects: Replenishing volume and immediate wrinkle improvement
• Mechanism of action: Physically lifts the skin
• Duration: 6 months to 1 year
• Characteristics: Acts quickly, but may create an unnatural sense of volume

Pluryal Silk

• Main effects: Wrinkle improvement, better skin quality, and the creation of natural firmness
• Mechanism of action: Promotes cell regeneration and collagen production
• Duration: 6 months to 1 year
• Characteristics: The effect appears gradually, allowing for natural rejuvenation

Rather than the immediate volume of a hyaluronic acid injection, Pluryal Silk (PLURYAL SILK) achieves a natural rejuvenating effect by enhancing the skin's own functions. It can also offer benefits that are difficult to achieve with hyaluronic acid injections, such as improving dark circles.

3. Comparison with laser treatment

Laser treatment

• Main effects: Skin tightening and improvement of pigmentation
• Mechanism of action: Encourages skin regeneration through thermal energy
• Duration: Varies with the effect, but usually 6 months to 1 year
• Characteristics: Involves downtime and often requires multiple treatments

Pluryal Silk

• Main effects: Wrinkle improvement, better skin quality, and improvement of dark circles
• Mechanism of action: Promotes cell regeneration and collagen production
• Duration: 6 months to 1 year
• Characteristics: Almost no downtime, with makeup possible the same day

Compared with laser treatment, Pluryal Silk (PLURYAL SILK) involves almost no downtime and places less of a burden on patients. It can also offer benefits that are difficult to achieve with laser treatment, such as improving dark circles.

Summary

Pluryal Silk is chosen by many people for the following reasons:

1. A comprehensive improvement effect: It can simultaneously address various eye-area concerns such as wrinkles, sagging, dark circles, and skin quality.
2. Natural finish: Because it enhances the skin's natural functions, it delivers a rejuvenating effect with no unnatural appearance.
3. Long-term effects: Beyond just temporary improvement, continued use gradually improves the skin's condition.
4. Gentle on the skin and low risk: Because it uses high-purity PN, the risk of allergy is extremely low, making it suitable even for those with sensitive skin.
5. Minimal downtime: You can return to daily life right after the procedure, with makeup possible the same day.
6. The possibility of combining it with other treatments: Combining it with other treatments such as botulinum toxin or laser therapy may deliver even greater results.

Thanks to these features, Pluryal Silk is drawing attention as a new standard for eye area treatment. However, depending on the individual case and the desired results, other treatments or a combination of treatments may be more appropriate. Please consult our physicians about the best treatment option for you.

We hope that Pluryal Silk can be your first step toward regaining a beautiful, confident look. For more details or an individual consultation, we invite you to book a consultation.

CLINIC LIST

Clinic List

Jimbocho Clinic

〒101-0054
3-16-1 Kanda Nishiki-cho, Chiyoda-ku, Tokyo, EX Kanda Nishiki-cho Building 8F (general reception) / 7F

Hours: Mon–Fri 11:00–20:00 / Sat & Sun 10:00–19:00

Yokohama Clinic

〒221-0835
TS Plaza Building 2F, 2-23-2 Tsuruya-cho, Kanagawa-ku, Yokohama-shi, Kanagawa

Hours: 10:00–19:00